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Fig. 6 | Molecular Cancer

Fig. 6

From: Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer

Fig. 6

miR-155 and miR-27a lead to cancer metastasis and chemoresistance and attenuate the effect of shBmi-1 in vivo. a and b Imaging and quantification of metastatic nodules in liver specimens from metastatic models stablished by tail vein injection of BGC823 cells. Arrows show metastatic nodules. *P < 0.05 vs. NC mimic. c Hematoxylin and eosin (H&E) staining of BGC823 liver metastatic tumors. d and g Isolated tumors of xenograft models with intraperitoneal injections of PBS or 5-Fu. e and f The size and weight of subcutaneous tumors that were established by cells with stable overexpression of miR-155 or miR-27a and treated with 5-Fu. *P < 0.05 vs. PBS. h and i The size and weight of excised tumors from mice subcutaneously implanted with stably transfected cells. *P < 0.05 vs. PBS, **P < 0.01 vs. PBS, ***P < 0.001 vs. PBS

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Molecular Cancer

ISSN: 1476-4598