Fig. 5

The therapeutic potential of RBAT1 targeted GapmeRs in primary Rb cells. a A patient-derived xenograft (PDX) model was established using Rb primary cells derived from patients. b Real-time PCR showed that the expression of RBAT1 is upregulated in Rb primary cells compared with normal tissues. c-d General photograph (c) of tumor bearing eyeballs removed from the mice at the 35th day. d Top: the weight of tumors treated by intravenous injection with RBAT1 targeted GapmeR (GapmeR1; n = 8), and scrambled GapmeR (Ctrl; n = 8). Bottom: H&E staining to evaluate tumor formation. e-f Real-time PCR (e) and western blot (f) analysis showed that the expression level of RBAT1 in orthotopic xenograft after intravenous treatment of lncRBAT1 targeted GapmeRs. The results were shown as Mean ± SD, **p < 0.01