Fig. 4

Possible targets harnessing NK cells in cancer therapy. In order to obtain better clinical efficacy and reduced severe adverse events, the development of NK cell-based therapies that support NK cell maintenance (a), enhance NK cell function (b) and harness abnormal immunometabolic and intracellular microenvironment (c) is essential. rhIL-12/15/18, recombinant human interleukin-12/15/18; CAR-iPS, chimeric antigen receptor-induced pluripotent stem cell; MIC: MHC I chain related molecule; MICA, MHC class I polypeptide-related sequence A; MICB, MHC class I polypeptide-related sequence B; PD-L1, programmed cell death-ligand 1;scFv, single-chain variable fragment; TSA, tumor specific antigen; BiKE, bispecific killer cell engager; TriKE, trispecific killer engager; CAR-NK, chimeric antigen receptor-nature kill; PD-1, programmed cell death protein 1; MerTK, MER proto-oncogene, tyrosine kinase; 27HC, 27-hydroxycholesterol; GLUT1, glucotransporter 1; MCT1, monocarboxylate transporter 1