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Table 1 Key mediators of NK cells

From: Natural killer cells in cancer biology and therapy

Classification Mediator Host ligand Ref.
NK cell activator
 MHC-I specific receptor KIR2DS1, 2DS3, 3DS5 MHC I [28]
Ly49c, Ly49i MHC I [29]
NKp80 MHC I [30]
NKG2C, NKG2E MHC I [31]
 MHC-I related receptor NKG2D MICA, MICB, ULBPs [13]
 MHC-I non-related receptor DNAM1 Nectin-2, CD155 [32]
NKp46 (NCR1) HS GAGs, CFP [33]
NKp44 (NCR2) HS GAGs, MLL5, NKp44L, PCNA, BAT3, PDGF-DD, Nidogen-1 [34]
NKp30 (NCR3) HS GAGs, B7-H6, Galectin-3 [35]
Nkp65 Keratinocyte-associated C-type lectin [36]
LFA-1 (αLβ2 integrin) Intercellular cell adhesion molecule 1 [37, 38]
α4 integrin Vascular cell adhesion molecule 1 [39]
CD16 Fc-γ [40, 41]
CD2 CD581 [41]
TLR3 Microbial constituents, adjuvant [42]
TLR9 CpG [43]
NK cell inhibitor
 MHC-I specific receptor KIR3DL1 MHC I [44]
KIR2DL3, 2DL1 MHC I [45]
NKG2A MHC I [46]
KLRB1, LLT1 MHC I [47]
LILRB1, LILRB2 MHC I [48]
 MHC-I non-related receptor KLRG1 E-, N-, and R- cadherins [49]
siglec-3, siglec-7, siglec-9 Sialic acid [50, 51]
CEACAM1 CEACAM1, CEACAM5 [52]
2B4 (CD244) CD48 [53]
IRp60 Phosphatidylserine [54]
LAIR1 Ep-CAM [55]
CD96 CD155 [56]
CD73 Antibodies [57]
PD-1 PD-L1 [58]
TIGIT CD155 [20]
NKR-P1B Clr-b [59]
LAG3 MHC-II [60]
  1. Abbreviations: MHC major histocompatibility complex, KIR killer cell immunoglobulin-like receptor, MIC MHC class I chain-related, ULBP UL16-binding protein 1, DNAM1 DNAX accessory molecule 1, NCR natural cytotoxicity receptor, HS GAGs heparan sulfate glycosaminoglycans, CFP complement factor P, MLL5 mixed-lineage leukemia protein-5, PCNA proliferating cell nuclear antigen, BAT3 HLA-B-associated transcript 3, PDGF-DD platelet-derived growth factor-DD, LFA-1 lymphocyte function-associated antigen-1, TLR toll-like receptor, KLR killer cell lectin-like receptor, LLT1 lectin-like transcript 1, LILR leukocyte immunoglobulin-like receptor, Siglec sialic acid-binding immunoglobulin-like lectin, CEACAM carcinoembryonic antigen-related cell-adhesion molecule, IRp60 inhibitory receptor protein 60, LAIR1 leukocyte-associated immunoglobulin-like receptor 1, Ep-CAM epithelial cellular adhesion molecule, PD-1 programmed cell death protein 1, TIGIT T-cell immunoreceptor with Ig and ITIM domains, LAG3 lymphocyte activation gene 3