Table 1 Representative circRNAs with clear mechanisms, biological functions and clinical significance in cancers
From: CircRNAs in anticancer drug resistance: recent advances and future potential
Mechanism | Cancer | CircRNA | Expression | Biological functions | Clinical significance | Ref |
|---|---|---|---|---|---|---|
Transcriptional regulation | Lung cancer | circNOL10 | Down | Inhibit cell proliferation and promote cell apoptosis; | Lung cancer differentiation | [29] |
Colorectal Cancer | circITGA7 | Down | Inhibit cell growth and metastasis; | Tumor size; Lymph metastasis; Distant metastasis and TNM stage; | [30] | |
Breast Cancer | circFECR1 | Up | Promotes tumor metastasis; | Metastases; Advanced stages; | [31] | |
MiRNA sponging | Lung cancer | circPVT1 | Up | Promote cell proliferation and Inhibit cell apoptosis; | Tumor size; TNM stage; Overall survival; | [32] |
circFADS2 | Up | Promote proliferation and invasion; | TNM; LNM; Overall survival; | [33] | ||
circPTPRA | Down | Inhibit proliferation and migration; | Metastasis; Overall survival; | [34] | ||
Gastric Cancer | circHIPK3 | Up | Promote proliferation and migration; | Overall survival; Infiltrative type GC cell; Advanced TNM stage; | ||
circPVT1 | Up | Promote proliferation; | Overall survival; Disease-free survival; | [37] | ||
circLARP4 | Down | Inhibit proliferation and invasion; | Overall survival; | [38] | ||
Colorectal cancer | circHIPK3 | Up | Promote proliferation, migration, invasion, metastasis, autophagy and inhibit apoptosis; | Advanced TNM stage; Lymph node metastasis, Distant metastasis; Advanced tumor; | [39] | |
circ_0021977 | Down | Inhibit proliferation, migration, and invasion; | TNM stage; Overall survival; | [40] | ||
Hepatocellular carcinoma | circHIPK3 | Up | Proliferation, migration | Tumor differentiation; Advanced TNM stage; HBV-DNA copy numbers; Liver cirrhosis; | [41] | |
circ_0001649 | Down | Inhibit proliferation and migration | Differentiation and tumor Satellite; | [42] | ||
Bladder cancer | circHIPK3 | Down | Inhibit Migration, invasion and angiogenesis. | Advanced tumor; Lymph node metastasis; | [43] | |
Protein interaction | Gastric cancer | circ-DONSON | Up | Facilitate cancer growth and invasion | TNM stage; Lymph node metastasis; Overall survival and Disease-free survival; | [44] |
circAGO2 | Up | Promote growth, invasion, and metastasis | Metastasis; Overall survival; | [45] | ||
Self-translation | Glioblastoma | circ-SHPRH | Down | Suppress tumor progression and tumorigenesis | Overall survival; | [46] |
circFBXW7 | Down | Inhibit proliferation and cell cycle acceleration. | Overall survival; | [47] |