Table 1 Available exosomes involved in pancreatic cancer diagnosis
From: The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
Type of cancer | Used samples during the studies | Exosomes | Application in pancreatic cancer | References |
|---|---|---|---|---|
Pancreatic cancer | Exosomes were collected from the conditioned media of pancreatic cancer cell lines and plasma samples of localized pancreatic cancer patients (Stage I-IIA) healthy subjects. | miR-196a and miR-1246 | Diagnosis | [57] |
The exosomes were collected from patients with pancreatic cancer, and patients without neoplasms (controls). | miR-191, miR-21, miR-451a | Diagnosis | [58] | |
Plasma RNAs were extracted from pancreatic cancer patients, chronic pancreatitis patients, and healthy controls. | miRNA-16a and miRNA-196a, together with CA19–9 | Diagnosis | [62] | |
The plasma samples were obtained from pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasm (IPMN) patients, and healthy controls. | miRNA-483-3p | Diagnosis | [59] | |
Saliva from pancreatobiliary tract cancer patients, healthy donors. | miR-1246 and miR-4644 | Diagnosis | [66] | |
Portal vein blood and peripheral blood collected from PDAC patients during curative pancreatectomy. | miR-4525, miR-451a, and miR-21 | Diagnosis | [63] | |
The plasma of patients with primary pancreatic ductal adenocarcinoma and plasma from healthy controls. | miR-155, miR196a | Diagnosis | [67] | |
Serum from pancreatic cancer, chronic pancreatitis, and benign pancreatic tumors patients, also they used serum from non-pancreatic cancer. | miR-1246, miR-4644, miR-3976, miR-4306 and CD44v6, Tspan8, EpCAM, MET, CD104 | Diagnosis | [24] | |
The peripheral blood plasma of patients with PC and healthy controls. | exmiR-21 | Diagnosis | [68] | |
Serum, benign pancreatic tumors, ampullary carcinomas, chronic pancreatitis, healthy donors. | miR-17-5p | Diagnosis | [69] | |
The plasma of pancreatic cancer, chronic pancreatitis patients, and healthy controls. | miR-10b | Diagnosis | [70] | |
The exosomes have been extracted from media that contained the PANC1 cell line. | miR-550 | Diagnosis | [71] | |
The exosomes were collected from the blood of pancreatic cancer, chronic pancreatitis patients, normal donors. | microRNA-10b, (miR-10b), miR-21, miR-30c, and miR-181a and low miR-let7a | Diagnosis | [72] |