Fig. 2From: cGAS-STING pathway in cancer biotherapyliposomal cGAMP structure and therapeutic strategy. a) DOTAP: 1,2-dioleoyl-3-trimethylammonium-propane, DSPE-PEG (2000): 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] polyethylene glycol; b) The injection of liposomal cGAMP in melanoma tumor-bearing mice are conducted. cGAMP alone cannot be transported into the cytosol. Liposomal cGAMPs are taken up, facilitating the release of cGAMP into the cytosol. Then, the cGAS-STING pathway is activated in the APC. Reprinted from [122], copyright (2017) WileyBack to article page