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Fig. 3 | Molecular Cancer

Fig. 3

From: cGAS-STING pathway in cancer biotherapy

Fig. 3

T-MPs function. Upon UV irradiation, tumor cells release MPs containing tumor antigens and DNA fragments. T-MPs present DNA fragments from cancer cells for APC, stimulating the production of type I IFNs by the activation of the cGAS-STING pathway. Type I IFNs, in turn, make DCs mature by up-regulating CD80, CD86 and MHCII. DCs present tumor antigens to T cells, eliciting anti-tumor effects. Reprinted from [129], copyright Taylor & Francis

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Molecular Cancer

ISSN: 1476-4598