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Fig. 2 | Molecular Cancer

Fig. 2

From: Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Fig. 2

The antitumor immunity effect of the cGAS-STING pathway. DNA damage leads to the formation of dsDNA in tumor cells, upon its stimulation, STING signaling is activated and promotes the release of Type I IFN, which is crucial for DC maturation. STING signaling activation in DCs is the core step of the whole cancer-immunity cycle, which can be initiated through engulfment of dying/damaged tumor cells, exosome transfer and cGAMP gap junctions. Then DCs migrate towards the tumor-draining lymph node and cross-prime tumor specific CD8+ T cells with the help of Type I IFNs. Finally, T cells undergo clonal expansion and traffic through the blood vessel to conduct tumor killing

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