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Fig. 5 | Molecular Cancer

Fig. 5

From: Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer

Fig. 5

Signal transduction pathways associated with NPTXR. a Epitope mapping of the amino acid sequence targeted by NPTXR-mAb-1 by ELISA. b Antibody-dependent cell-mediated cytotoxicity assay of MKN1 cells in the presence of CD20-mAb or NPTXR-mAb-1. c Overview of the antibody array results. Data are expressed as the fold-change induced by treatment of MKN1 cells with NPTXR-mAb-1 or by transfection with NPTXR-targeting siRNA. d Analysis of phosphorylated AKT levels in MKN1 or NPTXR-KO cells. e Hypothetical role of NPTXR in signaling pathways and cell phenotypes

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Molecular Cancer

ISSN: 1476-4598