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Fig. 4 | Molecular Cancer

Fig. 4

From: Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

Fig. 4

CDR1as suppresses gliomagenesis of U87MG cells in vitro and in vivo. a-d Colony formation assays (a), cell proliferation assays (b), flow cytometric cell cycle assays (c) and flow cytometric apoptosis assays (d) for U87MG cells treated with different siCDR1as or siNC. e Excised tumors from nude mice xenografted with U87MG cells treated with siCDR1as-1 or siNC. f Volume of xenografted tumors derived from U87MG cells treated with siCDR1as-1 or siNC. g Kaplan-Meier curves of the overall survival of nude mice xenografted with U87MG cells treated with siCDR1as-1 or siNC. h IHC assays for xenografted tumors derived from U87MG cells stained with H&E, PCNA antibody and p53 antibody respectively. *p < 0.05; **p < 0.01; ***p < 0.001; **** p < 0.0001

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