Fig. 5
From: Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis
CDR1as functions in a p53-dependent manner. a, b Ectopic expression (a), and knock-down (b) of CDR1as in HCT116 cells in which p53 is intact (HCT116p53+/+) or absent (HCT116p53−/−). c, d Colony formation assays for HCT116p53+/+ cells and HCT116p53−/− cells in which CDR1as is ectopically expressed (c) or knocked down (d). e Flow cytometric cell cycle assays (left) and apoptosis assays (right) for the indicated cells transfected with CDR1as expressing plasmid (or control plasmid). f Flow cytometric cell cycle assays (left) and apoptosis assays (right) for the indicated cells transfected with siCDR1as-1 (or siNC). *p < 0.05; **p < 0.01; ***p < 0.001