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Table 1 Phenotypic characterization of FBXW7 mutants

From: Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells

  NICD Cyclin E c-Myc MCL-1 BRAF
FBXW7 WT + + + + +
S462P - - - - -
H468R - - - - -
W425R - - - + -
L443F - - - /+ + +
W406R / T416A + + + + +
D510E /D527G - + + + +
R505C - - - - +
R465C - - - -  
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Molecular Cancer

ISSN: 1476-4598