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Fig. 1 | Molecular Cancer

Fig. 1

From: Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

Fig. 1

Identification of HtrA1 as a cisplatin resistance-related gene in NSCLC. a. The differential expression of genes in parental and NCI-H460/CDDP cells was compared using gene microarray analysis. The figure shows GO analysis (molecular function, MF) of the differentially expressed genes. Functions highlighted in red represent serine-type endopeptidase activity and serine-type peptidase activity. b and c. The differential expression of genes in NCI-H460 and NCI-H460/CDDP cells by b, gene microarray analysis and c, RT-PCR. d. GSEA analysis of PPAR, RAR and acetyltransferase activity in NCI-H460/CDDP cells. e. The activity of HDAC and RXR in CDDP resistant and parental cells. f. The protein expression levels of the main isoforms of HDAC and RXR in CDDP resistant cells and parental cells. *P < 0.05, as compared to the parental cell group with the CDDP-resistant cell group

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Molecular Cancer

ISSN: 1476-4598