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Fig. 2 | Molecular Cancer

Fig. 2

From: The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

Fig. 2

Molecular mechanism of m6A deposition in RNA, biological function and implications in human cancer. a-c m6A RNA methylation landscape in mRNA (a) and ncRNA (b & c) mediated by writers (blue balloons), including METTL3, METTL14, WTAP, RBM15B, KIAA1429, ZC3H13 and METTL16, erasers (pink balloons) FTO and ALKBH5 and reader proteins (yellow balloons) YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2 and HNRNPC, HNRNPG, HNRNPA2, HNRNPB1, IGF2BPs and eIF3, and their role in mRNA metabolism. d-g Aberrant m6A deposition in mRNA and ncRNAs promotes or suppresses tumour progression through METTL3/METTL14 upregulation (d) or downregulation (e) and FTO/ALKBH5 upregulation (f) or downregulation (g). Red arrows indicate induction. Blue arrows with flat end represent inhibition

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