Table 1 Overview of deregulated circRNAs in renal cell carcinoma (RCC)
From: Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy
CircRNA | Expression Change | Function | Target microRNA | miRNA target genes/protein | Reference |
|---|---|---|---|---|---|
circPCNXL2 | up | proliferation (+); invasion (+) | miR-153 | ZEB2 | [34] |
circ-0039569 | up | Proliferation (+); migration (+); invasion (+) | miR-34a-5p | CCL22 | [35] |
circ-ZNF609 | up | proliferation (+); invasion (+) | miR-138-5p | FOXP4 | [36] |
circNRIP1 | up | proliferation (+); migration (+) | miR-505 | AMPK and PI3K/AKT/mTOR | [37] |
circFNDC3B | up | cell viability (+); migration (+) | miR-99a | JAK1/STAT3 and MEK/ERK | [38] |
circ-001895 | up | proliferation (+); apoptosis (−); migration (+); invasion (+) | miR-296-5p | SOX12 | [39] |
circ-EGLN3 | up | proliferation (+); apoptosis (−); migration (+); invasion (+) | miR-1299 | IRF7 | [40] |
circ-000926 | up | proliferation (+); migration (+); invasion (+); EMT (+) | miR-411 | CDH2 | [41] |
circ-ZNF652 | up | proliferation (+); apoptosis (−); EMT (+) | miR-205 | Ras/Raf/MEK/ERK and JAK1/STAT3 | [42] |
circ-0035483 | up | autophagy (+); tumor growth (+); gemcitabine resistance (+) | miR-335 | CCNB1 | [43] |
circ-ABCB10 | up | proliferation (+); apoptosis (−); migration (+) | __ | __ | [44] |
circ-0072309 | down | proliferation (−); apoptosis (+); migration (−); invasion (−) | miR-100 | PI3K/AKT and mTOR | [45] |
circ-AKT3 | down | migration (−); invasion (−); EMT (−) | miR-296-3p | E-cadherin | [46] |
cRAPGEF5 | down | proliferation (−); migration (−); invasion (−) | miR-27a-3p | TXNIP | [47] |
circ-0001451 | down | proliferation (−); apoptosis (+) | __ | __ | [48] |
circHIAT1 | down | migration (−); invasion (−) | miR-195-5p miR-29a-3p miR-29c-3p | CDC42 | [49] |
circATP2B1 | down | migration (−); invasion (−) | miR-204-3p | FN1 | [50] |