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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit

Fig. 5

hsa_circ_0004872 regulates the proliferation, invasion and migration of GC cells via miR-224. a EdU analysis of the cell proliferation ability in SGC-7901 and BGC-823 cells cotransfected with pLCDH-circ+control mimics or pLCDH-hsa_circ_0004872 + control mimics or pLCDH-hsa_circ_0004872 + miR-224 mimics.Scale bar: 20 μm. b Statistical analysis of the EdU-positive cell ratio in the GC cells with different cotransfection. c CCK-8 analysis of the cell proliferation ability in cotransfected BGC-823 and SGC-7901 cells. d The scratch wound healing assays in BGC-823 and SGC-7901 cells with different cotransfection. Scale bar: 500 μm. e Statistical analysis of cell migration in the scratch wound healing assays. f Transwell invasion and migration assay in treated BGC-823 and SGC-7901 cells. Scale bar: 100 μm. g Statistical analysis of the cell numbers passing through the transwell chamber in treated BGC-823 and SGC-7901 cells. h Western blot analysis of the protein expression level of p21 and Smad4 in BGC-823 and SGC-7901 cells with different cotransfection. All datas were the means ± SD

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