Skip to main content
Fig. 7 | Molecular Cancer

Fig. 7

From: Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit

Fig. 7

ADAR1 is up-regulated in GC tissues and regulates the expression of hsa_circ_0004872 in GC cells. a The expression level of ADAR1 was detected with qRT-PCR and analyzed with paired t-tests in GC tissues and the adjacent nontumor tissues (n = 39, p = 0.0053). b The Kaplan-Meier Plotter database (201786_s_at) analyzed the ADAR1 levels in relation to the overall survival of patients with GC. c The Kaplan-Meier Plotter database (201786_s_at) analyzed the ADAR1 levels in relation to the overall survival of patients with lymph node metastasis of GC. d qRT-PCR analysis of the mRNA expression level of ADAR1 in GC cells transfected with ADAR1 siRNA (si-ADAR1) or control siRNA (si-NC). e Western blot analysis of ADAR1 protein level in BGC-823 and SGC-7901 cells transfected with ADAR1 siRNA or control siRNA. f qRT-PCR analysis of the expression level of hsa_circ_0004872 in GC cells transfected with ADAR1 siRNA or control siRNA. g Western blot analysis of the expression level of ADAR1 and the label myc in BGC-823 and SGC-7901 cells transfected with ADAR1 overexpression vector (ADAR1-p110 and ADAR1-p150) or the control vector (p-3 × flag). h qRT-PCR analysis of the mRNA level of ADAR1 in BGC-823 and SGC-7901 cells transfected with ADAR1 overexpression vector or the control vector. i qRT-PCR analysis of hsa_circ_0004872 expression in BGC-823 and SGC-7901 cells transfected with ADAR1 overexpression vector or or the control vector. j qRT-PCR analysis of miR-224 expression in BGC-823 and SGC-7901 cells with different cotransfection. All datas were the means ± SD

Back to article page

Molecular Cancer

ISSN: 1476-4598