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Fig. 1 | Molecular Cancer

Fig. 1

From: circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2

Fig. 1

The expression and characteristics of circCUL2 in GC tissues and cells. a: qRT-PCR of circCUL2 expression in GC tissues. b: The ROC curve to evaluate the diagnostic value of circCUL2. c: Kaplan-Meier analysis of the correlation between circCUL2 expression and overall survival in 100 GC patients. d: Relative circCUL2 levels in serum from GC patients and healthy controls without GC (n = 48). e: The expression of circCUL2 in GC cells. f: Sanger sequencing of circCUL2. The arrows represent splicing sites. G and H: qRT-PCR determining the abundance of circCUL2 and linear CUL2 in the AGS (g) and SGC-7901 (h) cell lines after RNase R treatment. i: qRT-PCR products of linear and circular products amplified with convergent and divergent primers with and without RNase R treatment. j: qRT-PCR analysis of circCUL2 and CUL2 after actinomycin D treatment. k: qRT-PCR of separated nuclear and cytoplasmic fractions. l: FISH for circCUL2 localization in AGS and SGC-7901 cell lines

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