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Fig. 3 | Molecular Cancer

Fig. 3

From: circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2

Fig. 3

circCUL2 functions as a miR-142-3p sponge. a: The expression of linear CUL2 in GC tissues. b: The correlation of circCUL2 and CUL2 (P = 0.179). c: Neither knockdown nor overexpression of circCUL2 modulated linear CUL2 expression in GC cells. d: CircInteractome and circRNABase were used to predict the potential target miRNAs that bind to circCUL2. e: Heatmap of miRNA sequencing data (GSE89143). f: The expression of miR-142-3p and miR-653 in AGS and SGC-7901 cells transfected with circCUL2-specific siRNA or overexpression plasmids. g: The target genes of miR-142-3p predicted by miRanda, miRBridge, PicTar, PITA and TargetScan. h: The expression of screened miR-142-3p target genes (RAC1, ITGAV, ROCK2, CLTA and CRK) in AGS and SGC-7901 cells transfected with circCUL2-specific siRNA or miR-142-3p mimics

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Molecular Cancer

ISSN: 1476-4598