Fig. 6

circCUL2 regulates the sensitivity of GC cells to cisplatin. a: Kaplan-Meier analysis of the correlation between miR-142-3p expression and DFS (left) or DFS with chemotherapy (right). b: The correlation between ROCK2 expression and DFS (left) or DFS with chemotherapy (right). c: Relative viability of circCUL2 overexpression plasmid- or siRNA-transfected cells exposed to cisplatin at the indicated concentrations for 48 h. d: The IC50 of AGS and SGC-7901 cell lines treated with cisplatin. e: The mRNA levels of circCUL2, miR-142-3p and ROCK2 in the GSE-1, AGS, AGS/DDP, SGC-7901 and SGC-7901/DDP cell lines. f-i: Cell growth f, IC50 g, apoptosis ((flow cytometry) h, and TUNEL assays i of AGS/DDP cell lines cotransfected with miR-142-3p mimics and circCUL2 overexpression plasmids. j: Xenograft tumors of sacrificed mice treated with or without cisplatin at the experimental endpoint. k: Tumor volumes of nude mouse tumors. l: The mRNA levels of circCUL2, miR-142-3p and ROCK2 in mice tumor tissues