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Fig. 1 | Molecular Cancer

Fig. 1

From: circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Fig. 1

High p62 level is associated with malignant progression and poor prognosis of LSCC patients. Protein levels of p62 in 138 LSCC tissues and 41 ANM tissues (Cohort 1) were determined by IHC staining. a Representative image of p62 IHC staining in LSCC tissues and paired ANM tissues. Scale bar, 20 μm. b IHC staining results of p62 in 41 paired LSCC tissues and ANM tissues were quantified with CaseViewer version 2.3 and presented as H-Score. c Representative confocal microscopy images of LC3B dots (green) in formalin-fixed paraffin-embedded LSCC tissues and paired ANM tissues, nuclei were stained with DAPI (blue). Scale bar, 20 μm. d-g Differential expression of p62 protein in 138 LSCC tissues with different T stages (d), N stages (e), clinical stages (f), and pathological differentiation degrees (g). The difference of H-score of p62 between two groups was analyzed by Two-tailed Student’s t-test. h Kaplan-Meier analysis of the association between p62 protein levels and overall survival in 138 LSCC patients. Expression levels of p62 were divided into high and low subgroups according to the median H-score of IHC staining

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Molecular Cancer

ISSN: 1476-4598