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Fig. 11 | Molecular Cancer

Fig. 11

From: circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

Fig. 11

Silencing of circPARD3 suppresses tumorigenicity and enhances chemosensitivity of LSCC cells in vivo. a Effects of circPARD3 on LSCC xenograft tumor growth and chemosensitivity in vivo. Left: Representative images of tumors in nude mice after subcutaneous injection of FD-LSC-1 cells with circPARD3 knockdown (sh-circPARD3) and treated with Cisplatin (n = 6). Right: Tumor growth curve was plotted using xenograft tumor volume data. b Tumor weight was measured after tumor excision. c The relative expression levels of circPARD3 and miR-145-5p in xenograft tumors were determined by qPCR analysis. d Hematoxylin and eosin staining revealed the structure of xenograft tumors. Scale bar, 20 μm. e IHC staining of PRKCI, p-AKT(S473), p-mTOR, p62 and immunofluorescence of LC3B in xenograft tumors. Scale bar, 25 μm. f IHC staining of Ki-67, E-cadherin, N-cadherin, and Vimentin in xenograft tumors. Scale bar, 25 μm. g Schematic illustration indicates the mechanism by which circPARD3 inhibits autophagy to promote malignant progression and chemoresistance of LSCC via activating the PRKCI–Akt–mTOR pathway. NS, Normal Saline. Data are mean ± SD. *P < 0.05, **P < 0.01

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