Fig. 1
From: Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer
The dysregulated non-canonical sncRNAs in lung cancer. a The co-expression pattern tsRNA subcategories across the PBMC samples in the discovery cohort. The correlation coefficient was calculated by Spearman’s rank correlation test. tsRNA-Ala, tsRNA-Asn, tsRNA-Leu, tsRNA-Lys, and tsRNA-Tyr were strongly and positively correlated with each other. b The expression profile of tsRNA-Ala, tsRNA-Asn, tsRNA-Leu, tsRNA-Lys, tsRNA-Tyr, rsRNA-5S, and ysRNA-RNY1 among the control, lung cancer, and TB subjects. RPM: reads per million. c and d The coverage profile of the PBMC rsRNA-5S and ysRNA-RNY1 sequences along rRNA-5S and YRNA-RNY1, respectively. The solid curves indicate the mean RPM values for the control, lung cancer, and TB groups. The colored bands represent the 95% confidence interval. nt: nucleotide. rsRNA-5S sequences were primarily derived from the 3′-end of rRNA-5S, whereas ysRNA-RNY1 sequences were largely derived from the 5′-end of YRNA-RNY1 with a small portion of fragments mapped to the 3′-end of YRNA-RNY1. e Expression heatmap of the sncRNA species within the TRY-RNA signature in the discovery cohort