Skip to main content

Table 1 Known circRNA-protein interactions classified by manners of action

From: Circular RNA: metabolism, functions and interactions with proteins

Manner CircRNA Protein Direct Effect Biological Function Correlationa Refs
Altering interactionsbetween proteins circFoxo3 p53, MDM2 induce mutant p53 ubiquitination pro-apoptosis P [92]
circFoxo3 p21, CDK2 dampen the activity and accessibility of CDK2 cell cycle arrest in G1 phase P [93]
circNfix YBX1, Nedd4l induce YBX1 ubiquitination and inhibit its nucleartranslocation cell cycle arrest, anti-angiogenesis,anti-regeneration U [25]
circADD3 CDK1, EZH2 phosphorylate EZH2 and induce its ubiquitination anti-metastasis P [94]
circAmotl1 PDK1, AKT phosphorylate AKT and promote pAKT nucleartranslocation anti-apoptosis, cardio-protection P [95]
circGLI1 p70S6K2, GSK3β phosphorylate GSK3β pro-metastasis P [96]
circCTNNB1 DDX3, YY1 transactivate YY1 tumor progression P [97]
circCUX1 EWSR1, MAZ transactivate MAZ pro-Warburg effect, tumor progression P [98]
circACC1 β and γ subunits of AMPK stabilize and activate AMPK metabolic reprogramming N [99]
circCcnb1 H2AX, (wild-type p53) free Bclaf1 from p53 cell survival P [100]
circCcnb1 H2AX, (Bclaf1) wrap Bclaf1 by H2AX cell death N [100]
circCcnb1 Ccnb1, CDK1 deactivate Ccnb1 and retain it in the cytoplasm cell cycle arrest in G2 phase N [101]
Blocking proteinsfrom DNA circHuR CNBP sequester CNBP from the HuR promoter tumor suppression N [102]
circSCMH1 MeCP2 tether MeCP2 and relieve its repression upon thetarget gene transcription neuroprotection post stroke P [103]
circSamd4 PURA, PURB tether PURA/B and relieve their repression uponMHC transcription pro-myogenesis U [104]
ACR DNMT3B tether DNMT3B and decrease the methylation of thePink1 promoter anti-autophagy U [105]
cia-cGAS cGAS block cGAS from self-DNA and inhibit its enzymatic activity maintaining HSCs quiescent U [106]
Blocking proteinsfrom RNA circSMARCA5 SRSF1 tether SRSF1 and suppress its splicing activity (SRSF3, PTBP1) anti-migration N [107]
circSMARCA5 SRSF1 tether SRSF1 and suppress its splicing activity (VEGFA) anti-angiogenesis N [108]
circPABPN1 HuR sequester HuR and destabilize PABPN1 mRNA anti-proliferation N [109]
circPABPN1 HuR sequester HuR and destabilize Atg16L1 mRNA anti-autophagy U [110]
circZKSCAN1 FMRP sequester FMRP from combing with CCAR1 mRNA anti-stemness, tumor quiescence U [111]
circMTO1 TRAF4 deactivate Eg5 translation chemosensitization U [112]
circMMP9 AUF1 relieve the inhibition of MMP9 mRNA pro-metastasis P [113]
circANRIL PES1 prevent pre-rRNA maturation and impair ribosome biogenesis anti-atherosclerosis N [114]
circPPM1F HuR sequester HuR and destabilize PPM1F mRNA M1 macrophage activation N [115]
Blocking proteinsfrom proteins circGSK3β GSK3β block GSK3β from β-catenin pro-metastasis N [116]
CDR1as p53 block p53 from MDM2 tumor suppression U [22]
circ102171 CTNNBIP1 block CTNNBIP1 from β-catenin tumor progression U [117]
circH19 PTBP1 tether PTBP1 and inhibit its ability to cleave and activate SREBP1 adipogenesis U [118]
circECE1 c-myc block c-myc from SPOP pro-Warburg effect P [119]
SCAR ATP5B block mPTP from CypD anti-metaflammation U [50]
Recruiting transcriptionfactors to chromatin circRHOT1 TIP60 recruit TIP60 to the NR2F6 promoter and initiate transcription tumor progression P [47]
circAnks1a YBX1 recruit YBX1 to the VEGFB promoter and activate transcription central sensitization, painbehavioral hypersensitivity U [120]
circ0005276 FUS recruit FUS to the XIAP promoter tumor progression P [121]
circPOK ILF2/3 complex potentiate the affinity of ILF2/3 to the IL-6 promoter pro-angiogenesis N [122]
Recruiting modifyingenzymes to chromatin circFECR1 TET1 induce demethylation and activate FLI1 transcription pro-tumorigenesis P [123]
circMRPS35 KAT7 induce the acetylation of H4K5 and activate FOXO1/3a transcription tumor suppression U [124]
circAGFG1 EZH2 induce H3K27me3 of the p53 promoter tumor progression U [125]
circLRP6 LSD1, EZH2 induce H3K27me3 and H3K4me2 of the KLF2 and APC promoter tumor progression P [126]
Recruiting chromatinremodelers circDONSON NURF complex recruit the NURF complex to the SOX4 promoter and activate itstranscription tumor progression U [127]
circKcnt2 NuRD complex recruit the NuRD complex to the Batf promoter and inhibit itstranscription anti-inflammation U [128]
Ternary complexesregulating RNA stability circNSUN2 IGF2BP2, (HMGA2 mRNA) stabilize HMGA2 mRNA pro-metastasis P [43]
circPOK ILF2/3, (mRNA of IL-6 andVEGF) stabilize the mRNA of IL-6 and VEGF tumor progression, pro-angiogenesis N [122]
circFNDC3B IGF2BP3, (CD44 mRNA) stabilize CD44 mRNA tumor progression P [129]
Ternary complexesregulating translation circMALAT1 Ribosome, (PAX5 mRNA) retard PAX5 translation self-renewal of HCC stem cells U [130]
circYap eIF4G, PABP, (Yap mRNA) interrupt the assembly of Yap translation initiation machinery tumor suppression N [131]
circMYBL2 PTBP1, (FLT3 mRNA) promote FLT3 translation AML progression P [132]
Translocating proteinsto the nucleus circAmotl1 c-myc retain c-myc in the nucleus and increase its affinity to targets pro-tumorigenesis P [46]
circAmotl1 STAT3 facilitate the nuclear translocation of STAT3 pro-wound repair P [133]
circDNMT1 p53, AUF1 facilitate the nuclear translocation of p53 and AUF1, elevatingLC3B level and stabilizing DNMT1 mRNA, respectively pro-autophagy, anti-senescence,tumor progression P [134]
circABCC1 β-catenin redistribute β-catenin tumor progression U [135]
circSOX4 β-catenin translocate β-catenin to the nucleus tumor progression P [136]
Translocating proteinsto the cytoplasm circFoxo3 ID-1, E2F1, FAK, HIF1α retain these proteins in the cytoplasm and arrest their functions pro-senescence P [137]
circFOXP1 PTBP1 translocate PTBP1 to the cytoplasm and stabilize PKLR mRNA pro-Warburg effect, tumor progression N [138]
circSTAG1 ALKBH5 retain ALKBH5 in the cytoplasm anti-depression U [139]
circBACH1 HuR translocate HuR to the cytoplasm cell cycle progression P [140]
circZFP609 HIF1α retain HIF1α in the cytoplasm anti-angiogenesis U [141]
circCCAC1 EZH2 retain EZH2 in the cytoplasm pro-metastasis P [24]
Other regions circERBB2 PA2G4 translocate PA2G4 to the nucleolus and promote rDNA transcription tumor progression P [142]
circSKA3 Tks5, Integrin β1 recruit Tks5 to the membrane and co-localize with integrin β1;induce the formation of invadopodia pro-invasion, pro-metastasis P [143]
mecciND1, mecciND5 RPA32, hnRNPA1, TOM40 interact with TOM40 and facilitate the mitochondrial importationof RPA32 and hnRNPA1, respectively metabolism of mtDNA and mtRNA;not clear U [143]
mecciRNAs PNPASE control the mitochondrial importation of mecciRNAs not clear U [52]
Unknown orunconfirmedmanners circ0011460 PGT just verify the interaction by RIP; increase PGT level positive correlation with pre-eclampsia P [144]
circ0075932 PUM2 just verify the interaction by RNA pull-down; increase PUM2 level pro-inflammation, pro-apoptosis U [145]
circFndc3b FUS just verify the interaction by RIP; decrease FUS level pro-angiogenesis, anti-apoptosis P [146]
circZNF292 LDHA just verify the interaction by RIP; increase LDHA level pro-glycolysis N [147]
circAmotl1 pAKT just verify the interaction by RIP; activate AKT pathway chemoresistance P [148]
circ0075804 (circE2F3) HNRNPK stabilize E2F3 mRNA; the formation of ternary complex is notconfirmed pro-proliferation, anti-apoptosis P [149]
circPTK2 vimentin just verify the interaction by RNA pull-down tumor progression U [150]
circ406961 ILF2 just verify the interaction by RNA pull-down; decrease ILF2 leveland suppress the STAT3/JNK pathway anti-inflammation (induced by PM2.5) U [151]
circBbs9 Ccnd2 just verify the interaction by RIP; increase Ccnd2 level pro-proliferation U [152]
circHECTD1 ZC3H12A reduce ZC3H12A ubiquitination by attenuatinginteraction between ZC3H12A and HECTD1; this study only showscircHECTD1 negatively correlates with HECTD1 deactivation and pro-apoptosis ofalveolar macrophage activated bysilica N [153]
circFOXK2 YBX1, hnRNPK enhance the interaction of YBX1 and hnRNPK with NUF2 andPDXK; lack a detailed mechanism tumor progression N [154]
circMUC16 ATG13 just verify the interaction by RNA pull-down; increase ATG13 level pro-autophagy P [155]
circUBR5 QKI, NOVA1 (U1 snRNA) probably participate in RNA splicing; lack a detailed mechanism non-functional phenotype U [156]
circNF1–419 Dynamin-1, Adaptor protein2 B1 (AP2B1) just verify the interaction by RNA pull-down and RIP; lack a detailed mechanism pro-autophagy, senile dementiadelay U [157]
circNOL10 SCML1 just verify the interaction by RNA pull-down; increase SCML1 level tumor suppression U [158]
circHipk3 Notch1 intracellular domain(N1ICD) verify the interaction by RNA pull-down and RIP; increase N1ICDexpression, stability, acetylation; lack a detailed mechanism cardiac regeneration U [159]
  cIARS ALKBH5 inhibit the ALKBH5-mediated interaction between Beclin1 andBcl-2; lack a detailed mechanism pro-autophagy, pro-ferroptosis U [160]
  1. aapproximate functional correlation between circRNAs and their parental genes. P positive, N negative, U unknown or unrelated