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Fig. 2 | Molecular Cancer

Fig. 2

From: Programmable N6-methyladenosine modification of CDCP1 mRNA by RCas9-methyltransferase like 3 conjugates promotes bladder cancer development

Fig. 2

Targeting of the CDCP1 m6A by RCas9-M3 facilitates bladder cancer (BC) development. a-c Targeted methylation by the RCas9-M3 system facilitates cancer progression in vitro. a MTT assay of cellular proliferation in SV-HUC-1 and METTL3-depleted T24 cells expressing the RCas9-M3 system. b RCas9-M3 targeting of CDCP1 mRNA promotes cell migration. Scale bars: 100 μm; 200×. c RCas9-M3 targeting of CDCP1 mRNA promotes cell invasion. Scale bars: 100 μm; 200×. d-f Targeted methylation by the RCas9-M3 system facilitates cancer progression in vivo. Representative tumor images d, weights e, and growth curves f are shown (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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Molecular Cancer

ISSN: 1476-4598