Fig. 2

Summary schematic of MITF regulation by oncogenic pathways and the intersection of MITF with the immune system at the post-translational level. Oncogenic signaling pathways (WNT/β-catenin, PI3K/AKT and BRAF) in melanoma cells as well as the tumor microenvironment signals all converge to regulate MITF levels and/or activity and immune function, favoring immunosuppression. By interacting with KARS1, repressing PD-L1 expression and reducing cytokine secretion MITF favors immunosurveillance