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Fig. 3 | Molecular Cancer

Fig. 3

From: Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

Fig. 3

Blood circulation and biodistribution of Nano-FdUMP. 5-Fu and Nano-FdUMP were i.v. injected into orthotopic CRC and HCC mouse models. a) The concentration of fluorine drug on different time points was plotted (n = 4). Half-life of 5-Fu and Nano-FdUMP was assessed using a one-compartmental model. b) Twelve hours post i.v. administration, the distribution of Did-labeled nanoformulations into tissues and tumors was detected (640 nm/670 nm) using IVIS® Kinetics Optical System (n = 4, * p < 0.05) in mice grafted with CRC. c) Twelve hours post i.v. administration, the distribution of Did-labeled nanoformulations into tissues and tumors was detected (640 nm/670 nm) using IVIS® Kinetics Optical System (n = 4, * p < 0.05) in mice grafted with HCC. In HCC model, AEAA-targeted nanoformulation was specifically accumulated inside liver tumor, which was confirmed by the colocalization of NPs (fluorescent imaging from DiD dye) and tumor tissue (bioluminescence imaging from visible light produced by the interaction between luciferase and luciferin)

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Molecular Cancer

ISSN: 1476-4598