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Fig. 4 | Molecular Cancer

Fig. 4

From: Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

Fig. 4

Synergistic ICD effects achieved by Nano-FdUMP and Nano-Folox. a) The exposure of CRT in CT26 and Hepa1–6 cells treated with PBS, Nano-FdUMP, Nano-Folox, and Nano-Folox/Nano-FdUMP following incubation with or without NAC (n = 3, * p < 0.05, ** p < 0.01, and no significance = NS). b) The release of ATP from CT26 and Hepa1–6 cells into the extracellular milieu treated with PBS, Nano-FdUMP, Nano-Folox, and Nano-Folox/Nano-FdUMP following incubation with or without NAC (n = 3, * p < 0.05). c) The secretion of HMBG1 in CT26 and Hepa1–6 cells treated with PBS, Nano-FdUMP, Nano-Folox, and Nano-Folox/Nano-FdUMP following incubation with or without NAC (n = 3, * p < 0.05)

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Molecular Cancer

ISSN: 1476-4598