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Table 1 Overview of circRNAs identifed by RNA sequencing and microarrays in BCa

From: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Sample Special treatment Detection Method GEO database Data source total circRNA Number of circRNA differently expressed (fold change ≥2) circRNAs validated by qRT-PCR Ref./PMID
4 paird BCa and BCN tissues RNAse R CircRNA microarray GSE92675 CircRNA microarray 3243 469 (285 upregulated, 184 downregulated) 6 27484176
3 paird BCa and BCN tissues rRNA-depleted and RNase R RNA-seq GSE97239 RNA-seq 16,353 (6154) 571 (47 upregulated, 524 downregulated) circ_HIPK3 28794202
1 paird BCa and BCN tissues rRNA-depleted RNA-seq GSE77661 RNA-seq 67,358(27296) / circ_HIPK3 27050392
4 paird BC and BCN tissues / RNA-seq / RNA-seq / 59(7 upregulated, 52 downregulated) hsa circ 0018069 30984788
2 paird BCa and BCN tissues RNAse R RNA-seq / RNA-seq 6834 567 40 30745833
5 paird BCa and BCN tissues rRNA and linear RNA-depleted RNA-seq / RNA-seq 88,732(62,788) 56 (14 upregulated, 42 downregulated) 2 29151929
4 paird BCa and BCN tissues rRNA-depleted RNA-seq / RNA-seq / 118 (34 upregulated, 84 downregulated) 3 30025927
9 different grades of BCa and BCN tissues / RNA-seq / RNA-seq / 244 (H vs L), 316 (H vs N), 42 circRNAs overlapped 7 31545480
BCa 5637, T24 and SV-HUC-1 cell lines / CircRNA microarray / CircRNA microarray / / circ_CASC15 31072448
10 paird BCa and HC urine samples Rnase R CircRNA microarray / CircRNA microarray / 86 (53 upregulated, 33 downregulated) circ_0137439 31777254
3 pairs of BCSCs and BCNSCs samples / CircRNA microarray / CircRNA microarray 4451 127 (113 upregulated, 14 downregulated) circ_103809 32065779
3 paird BCa and BCN tissues / CircRNA microarray / CircRNA microarray / 734 (478 upregulated, 256 downregulated) 8 30983072
3 paird BCa and BCN tissues Rnase R CircRNA microarray GSE112719 CircRNA microarray / 80 (37 upregulated, 43 downregulated) circ_101320 30305293
3 paird BCa and BCN tissues / CircRNA microarray / CircRNA microarray 1038 / 7 29558461
457 NMIBC samples / RNA-Seq / Bioinformatics analysis 15,223 / 13 29263845
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 469 (285 upregulated, 184 downregulated) circ_MYLK 28687357
3 paird BCa and BCN tissues / / GSE97239, GSE92675 Bioinformatics analysis / 18 (5 upregulated, 13 downregulated) 3 31169020
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 200 hsa_circ_0000144 30098434
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 408 circ_0058063 30362519
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 89 (66 upregulated, 23 downregulated) circ_0001429 30909190
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 433 (264 upregulated, 169 downregulated) circ_CEP128 30134837
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis 3423 433 (264 upregulated, 169 downregulated) circ_CEP128 30939216
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 312 (195 upregulated, 117 downregulated) circ_0058063 32181485
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / / circ_VANGL1 30146736
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis 3243 469 (285 upregulated, 184 downregulated) / 27363013
4 paird BCa and BCN tissues / CircRNA microarray GSE92675 Bioinformatics analysis / 428 (261 upregulated, 167 downregulated) hsa_circ_0011385 32015691
  1. circRNAs circular RNAs, BCa bladder cancer, BCN bladder cancer tissues paired adjacent normal bladder tissues, H high-grade bladder cancer, L low-grade bladder cancer, N normal tissue, HC healthy controls, BCSCs bladder cancer stem cells, BCNSCs bladder cancer non-stem cells, NMIBC non muscle-invasive bladder cancer