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Table 2 Dysregulated circRNAs in BCa

From: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Name CircBase ID Sponge target Gene Function Types of BCa tissues and BCa cell lines Ref./PMID
upregulated
circ_0058063 hsa_circ_0058063 miR-486-3p FOXP4 promoted cell proliferation, invasion, and inhibited apoptosis 94 cases of BCa and the non-cancerous normal tissues; 5637, BIU-87 and RT-112 cell lines 32181485
circ_0058063 hsa_circ_0058063 miR-145-5p CDK6 promoted cell proliferation and migration, inhibited cell apoptosis, and decreased cell cycle arrest 25 pairs of BCa tissues and adjacent normal tissues; T24 and J82 cell lines 30362519
circ_0017247 hsa_circ_0017247 / Wnt/β-catenin promoted cell proliferation and tumor formation, inhibited apoptosis, and decreased cell cycle arrest 50 BCa tissues and adjacent tissues; UM-UC3, SW780, BIU and J82 cell lines 32096177
circ_103809 hsa_circ_0072088 miR-511 / promoted the self-renewal, migration and invasion 3 pairs of BCa tissues and adjacent normal bladder tissues; T24 and EJ cell lines 32065779
circ_FNTA hsa_circ_0084171 miR-370-3p FNTA promoted invasion and decreased chemosensitivity to cisplatin 41 BCa tissues and adjacent normal bladder tissues; T24, J82, 5637, and UMUC3 cell lines 32052578
circ_PDSS1 hsa_circ_0093398 miR-16 / promoted cell proliferation, invasion and migration 72 BCa and adjacent healthy tissues; HT-1197 and UMUC3 cells 31868205
circ_403658 hsa_circ_0004383 / LDHA promoted cell growth and invasion 123 BCa tissues and the matched adjacent tissues; SW780, 5637, T24, J82 and RT4 cell lines 31814891
circ_0137439 hsa_circ_0137439 miR-142-5p MTDH promoted cell proliferation, migration, and metastasis 116 bladder cancer urine samples and 30 normal samples; T24 and 5637 cell lines 31777254
circ_VANGL1 hsa_circ_0002623 miR-605-3p VANGL1 promoted cell proliferation, migration, and invasion 87 BCa tissues and 37 normal adjacent tissues; T24 and EJ cells 30146736
circ_VANGL1 hsa_circ_0002623 miR-1184 IGFBP2 promoted cell proliferation, migration, and invasion 60 BCa and corresponding paracancerous tissue; J82, T24, EJ, RT-4, UM-UC-3, and TCC cell lines 31758655
circ_ZFR hsa_circ_0072088 miR-377 ZEB2 promoted cell growth, migration and invasion, and decreased cell cycle arrest and apoptosis 104 pairs of BCa tissues and adjacent normal tissues; UMUC3, T24, J82, 5637, SW780, EJ and BIU87 cell lines 31746333
circ_0001361 hsa_circ_0001361 miR-491-5p MMP9 promoted cell invasion and metastasis 69 pairs of BCa tissues and matched adjacent normal bladder epithelial tissues; SV-HUC-1, EJ, UMUC3, RT4, and 5637 cell lines 31705065
circ_UVRAG hsa_circ_0023642 miR-223 FGFR2 promoted proliferation, migration, tumor formation, and metastasis T24, EJ, J82, UM-UC-3, TCC, and RT-4 cell lines 30387298
circ_0023642 hsa_circ_0023642 miR-490-5p EGFR promoted cell invasion and metastasis J82 and UMUC3 cell lines 31455760
circ_CASC15 hsa_circ_0075828 miR-1224-5p CREB1 promoteed cell proliferation 67 pair BCa tissues and matched para-carcinoma tissues; 5637, and T24 cell lines 31072448
circ_0068871 hsa_circ_0068871 miR-181a-5p FGFR3 promoted cell proliferation and migration 32 BCa and adjacent normal tissue; T24, UMUC3, EJ, and J82 cell lines 30999937
circ_DOCK1 hsa_circ_0020394 miR-132-3p Sox5 promoted cell proliferation, migration, and tumour growth 23 BC tissue specimens and 32 normal bladder tissues; BIU-87, EJ-m3, T24 and 5673 cell lines 30983072
circ_CEP128 hsa_circ_0102722 miR-145-5p SOX11 promoted cell proliferation, and decreased cell apoptosis and cell cycle arrest 10 pairs of BCa tissues and adjacent bladder tissues; RT-112, 5637, BIU-87, TCCSUP and HEK293T cell lines 30134837
circ_CEP128 hsa_circ_0102722 miR-145-5p Myd88 promoted cell proliferation and migration, and decreased cell apoptosis and cell cycle arrest 40 BCa specimens and blood samples; 293T, J82 and T24 cell lines 30939216
circ_0001429 hsa_circ_0001429 miR-205-5p VEGFA enhanced cell propagation and metastasis, reduced cell apoptosis, and promoted tumor growth and lung metastasis 20 pairs of BCa tissues and paired adjacent normal bladder tissues; T24 cells and 5637 cells 30909190
circ_TFRC has_circ_0001445 miR-107 TFRC promoted the invasion, proliferation and tumor growth, contributed to an EMT phenotype 57 BCa patients tissues compared with adjacent normal patients tissues, EJ, T24, 5637, UMUC3, BIU87, J82, and SW780 cell lines 30782157
circ_ELP3 hsa_circ_0001785 / / promoted cell proliferation, and reduced apoptosis and chemosensitivity to cisplatin 18 pairs of tissue samples and 30 bladder cancer samples; T24 and 5647 cells 30745833
circ_PRMT5 hsa_circ_0031250 miR-30c SNAIL1/E-cadherin promoted cell EMT 119 UCB tissues with matched adjacent normal bladder tissues; T24, TCC-SUP, 5637, and UM-UC-3 cell lines 30305293
circ_BPTF hsa_circ_0000799 miR-31-5p RAB27A promoted cell migration and invasive, and tumor growth 72 pairs of specimens of BCa tissues and adjacent noncancerous tissues; UM-UC-3 and T24 cell lines 30103209
circ_0000144 hsa_circ_0000144 miR-217 RUNX2 promoted cell proliferation and invasion 21 pairs of BCa tissues and adjacent normal tissues; T24, EJ, UMUC3, RT4 and 253J cell lines 30098434
circ_PTK2 hsa_circ_0003221 / / promoted the proliferation and migration 40 pairs of BCa tissue and blood samples. T24 and 5637 cell lines 29125888
circ_MYLK hsa_circ_0002768 miR-29a VEGFA/VEGFR2 accelerated cell proliferation, migration, tube formation, and promoted EMT 32 pairs bladder carcinomas and matched para-carcinomas; EJ, T24, 5673 and BIU-87 cell lines 28687357
circ_TCF25 hsa_circ_0041103 miR-103a-3p/miR-107 CDK6 promoted proliferation and migration 40 pairs bladder carcinoma tissue and matched para-carcinoma tissues; T24 and EJ cell lines 27484176
downregulated
circ_FUT8 hsa_circ_0003028 miR-570-3p KLF10 inhibited migration, invasion, and metastasis 145 BCa tissues and 50 matched adjacent normal bladder tissues; T24, SV-HUC-1, and UM-UC-3 cell lines 32072011
circ_RIP2 hsa_circ_0005777 miR-1305 Tgf-β2/smad3 promoted migration, invasion, clone formation and EMT 45 paired BCa and the adjacent normal tissues, 58 bladder cancer tissues, 5637 and UM-UC-3 cell lines 32019579
circ_FAM114A2 hsa_circ_0001546 miR-762 ΔNP63/TP63 inhibited migration, invasion and proliferation 31 BCa tissues and paired adjacent noncancer tissues; T24, J82, 5637, and 293T cell lines 31969560
circ_0091017 hsa_circ_0091017 miR-589-5p / inhibited cell proliferation, migration and invasiveness 40 pairs of BCa tissues and normal adjacent tissues; 5637, EJ, T24, UMUC-3, and RT4 cell lines 31957821
ciRs_6 hsa_circ_0006260 miR-653 March1 suppressed cell growth and increased cell cycle arrest 45 paired bladder cancer and the adjacent normal tissues, 58 bladder cancer tissues; 5637 and UM-UC-3 cell lines 31819015
circ_5912 hsa_circ_0005912 / TGF-β signaling suppressesed cell proliferation, invasion and migration 58 BCa tissues and the matched adjacent tissues; T24 and SW780 cell lines 31808751
circ_PTPRA hsa_circ_0006117 miR-636 KLF9 inhibited cell proliferation and tumor growth 104 BCa specimens, 64 matched BC and adjacent normal specimens; T24 and UM-UC-3 cell lines 31821171
circ_Foxo3 hsa_circ_0006404 miR-191-5p / promoted cell apoptosis 30 BCa tissues and adjacent normal bladder tissues; T24, UM-UC-3 and J82 cell lines 31802888
circ_0071662 hsa_circ_0071662 miR-146b-3p HPGD/NF2 suppressed cell proliferation and invasion 97 BCa tissues and matched adjacent normal tissues; BIU-87, T-24, EJ-28 and J82 cell lines 31757227
circ_PICALM hsa_circ_0023919 miR-1265 STEAP4 inhibited cell invasion and metastasis 168 BCa samples and 40 corresponding adjacent normal tissue samples; T24, UM-UC-3, J82, RT-4, and HEK-293T cell lines 31648990
circ_0137606 hsa_circ_0137606 miR-1231 PHLPP2 suppressed cell proliferation and metastasis 13 high-grade BCa, low-grade BCa and a normal controlpatients tissues; T24 and SV-HUC-1 cell lines 31545480
circ-ZKSCAN1 hsa_circ_0001727 miR-1178-3p p21 inhibited cell proliferation, migration, invasion and metastasis 68 BCa tissues and the matched normal tissues; T24, UM-UC-3, 5637, and EJ cell lines 31481066
circ_NR3C1 hsa_circ_0001543 miR-27a-3p cyclin D1 inhibited cell proliferation, cell cycle progression, and tumor growth 42 pairs of BCa tissues and adjacent normal bladder tissues; T24, EJ, UMUC3, J82, and 5637 cell lines 31255724
circ_SLC8A1 hsa_circ_0000994 miR-130b/miR-494 PTEN inhibited cell migration, invasion and proliferation 70 pairs of human bladder cancer tissues compared with their adjacent normal tissues; 5637, T24, J82, EJ, UMUC, and RT4 cell lines 31228937
circ_Cdr1as hsa_circ_0001946 miR-1270 APAF1 induced cell apoptosis and enhanced chemosensitivity to cisplatin 160 BCa tissues; TCCSUP, 5367, T24 and EJ cell lines 31131537
circ_Cdr1as hsa_circ_0001946 miR-135a / inhibited cell proliferation, invasion and migration, and tumour growth 94 pairs of BCa tissues and adjacent normal tissues; EJ and T24 cell lines 29694981
circ_ACVR2A hsa_circ_0001073 miR-626 EYA4 suppressed cell proliferation and metastasis 50BC tissues and matched adjacent normal epithelial tissues; T24, UM-UC-3, RT4, J82, 5637, HT-1376, and TCCSUP cell lines 31101108
circ_0002024 hsa_circ_0002024 miR-197-3p / suppressed cell proliferation, migration, and invasion 20 BCa and normal samples; EJ, 5637, T24, and UMUC-2 cell lines 30972190
circ_CDYL hsa_circ_0008285 / C-MYC inhibited cell growth and migration 30 pairs of BCa tissues and paired surrounding normal bladder tissues; EJ and T24T cells 30968727
circ_LPAR1 hsa_circ_0087960 miR-762 / inhibited cell invasion and metastasis 125 BCa tissues and 68 paired cancer tissues and adjacent non-tumorous tissues; 5637 and T24 cell lines 30867795
circ_MTO1 hsa_circ_0007874 miR-221 / inhibited cell EMT and metastasis 117 bladder cancer tissues and the matched adjacent tissues; UMUC3, SVHUC1, T24, J82 and 5637 cell lines 30551873
circ_FNDC3B hsa_circ_0006156 miR-1178-3p G3BP2 inhibited cell proliferation, migration, invasion, tumorigenesis and metastasis 82 BCa tissues and 56 pairs of BCa tissues and adjacent noncancerous tissues; T24 and UM-UC-3 cell lines 30458784
circ_UBXN7 hsa_circ_0001380 miR-1247-3p B4GALT3 inhibited cell proliferation, migration, invasion, and tumor growth 84 cases of BCa tissues including 30 paired BC tissues and adjacent nontumor tissues; SV-HUC-1, T24 and UM-UC-3 cell lines 30312173
circ_HIPK3 hsa_circ_0000284 miR-558 HPSE inhibited cell migration, invasion, and angiogenesis, tumor growth, and metastasis 44 pairs of bladder cancer tissues and paired adjacent normal bladder tissues; UMUC3, and T24 cell lines 28794202
circ_BCRC3 hsa_circ_0001110 miR-182-5p p27 inhibited cell proliferation, and impairs tumor growth, and increased cell cycle arrest 47 BCa tissues and their adjacent normal bladder tissues; EJ,T24, and SV-HUC-1 cell lines 30285878
circ_BCRC4 hsa_circ_0001577 miR-101 EZH2 promoted cell apoptosis and inhibited cell viability 24 pairs of fresh bladder cancer tissues and surrounding normal adjacent bladder tissues; UMUC3 and T24 cell lines 29270748
circ_ITCH hsa_circ_0001141 miR-17, miR-224 p21, PTEN inhibited cell proliferation, migration, invasion and metastasis, induced cell cycle arrest and cell apoptosis 72 pairs of BCa tumor and normal tissues; UMUC3, T24, J82, 353J, 5637, TCC, EJ and RT4 cell lines 29386015
  1. circRNAs circular RNAs, BCa bladder cancer, EMT epithelial to mesenchymal transition