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Table 2 Dysregulated circRNAs in BCa

From: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Name

CircBase ID

Sponge target

Gene

Function

Types of BCa tissues and BCa cell lines

Ref./PMID

upregulated

circ_0058063

hsa_circ_0058063

miR-486-3p

FOXP4

promoted cell proliferation, invasion, and inhibited apoptosis

94 cases of BCa and the non-cancerous normal tissues; 5637, BIU-87 and RT-112 cell lines

32181485

circ_0058063

hsa_circ_0058063

miR-145-5p

CDK6

promoted cell proliferation and migration, inhibited cell apoptosis, and decreased cell cycle arrest

25 pairs of BCa tissues and adjacent normal tissues; T24 and J82 cell lines

30362519

circ_0017247

hsa_circ_0017247

/

Wnt/β-catenin

promoted cell proliferation and tumor formation, inhibited apoptosis, and decreased cell cycle arrest

50 BCa tissues and adjacent tissues; UM-UC3, SW780, BIU and J82 cell lines

32096177

circ_103809

hsa_circ_0072088

miR-511

/

promoted the self-renewal, migration and invasion

3 pairs of BCa tissues and adjacent normal bladder tissues; T24 and EJ cell lines

32065779

circ_FNTA

hsa_circ_0084171

miR-370-3p

FNTA

promoted invasion and decreased chemosensitivity to cisplatin

41 BCa tissues and adjacent normal bladder tissues; T24, J82, 5637, and UMUC3 cell lines

32052578

circ_PDSS1

hsa_circ_0093398

miR-16

/

promoted cell proliferation, invasion and migration

72 BCa and adjacent healthy tissues; HT-1197 and UMUC3 cells

31868205

circ_403658

hsa_circ_0004383

/

LDHA

promoted cell growth and invasion

123 BCa tissues and the matched adjacent tissues; SW780, 5637, T24, J82 and RT4 cell lines

31814891

circ_0137439

hsa_circ_0137439

miR-142-5p

MTDH

promoted cell proliferation, migration, and metastasis

116 bladder cancer urine samples and 30 normal samples; T24 and 5637 cell lines

31777254

circ_VANGL1

hsa_circ_0002623

miR-605-3p

VANGL1

promoted cell proliferation, migration, and invasion

87 BCa tissues and 37 normal adjacent tissues; T24 and EJ cells

30146736

circ_VANGL1

hsa_circ_0002623

miR-1184

IGFBP2

promoted cell proliferation, migration, and invasion

60 BCa and corresponding paracancerous tissue; J82, T24, EJ, RT-4, UM-UC-3, and TCC cell lines

31758655

circ_ZFR

hsa_circ_0072088

miR-377

ZEB2

promoted cell growth, migration and invasion, and decreased cell cycle arrest and apoptosis

104 pairs of BCa tissues and adjacent normal tissues; UMUC3, T24, J82, 5637, SW780, EJ and BIU87 cell lines

31746333

circ_0001361

hsa_circ_0001361

miR-491-5p

MMP9

promoted cell invasion and metastasis

69 pairs of BCa tissues and matched adjacent normal bladder epithelial tissues; SV-HUC-1, EJ, UMUC3, RT4, and 5637 cell lines

31705065

circ_UVRAG

hsa_circ_0023642

miR-223

FGFR2

promoted proliferation, migration, tumor formation, and metastasis

T24, EJ, J82, UM-UC-3, TCC, and RT-4 cell lines

30387298

circ_0023642

hsa_circ_0023642

miR-490-5p

EGFR

promoted cell invasion and metastasis

J82 and UMUC3 cell lines

31455760

circ_CASC15

hsa_circ_0075828

miR-1224-5p

CREB1

promoteed cell proliferation

67 pair BCa tissues and matched para-carcinoma tissues; 5637, and T24 cell lines

31072448

circ_0068871

hsa_circ_0068871

miR-181a-5p

FGFR3

promoted cell proliferation and migration

32 BCa and adjacent normal tissue; T24, UMUC3, EJ, and J82 cell lines

30999937

circ_DOCK1

hsa_circ_0020394

miR-132-3p

Sox5

promoted cell proliferation, migration, and tumour growth

23 BC tissue specimens and 32 normal bladder tissues; BIU-87, EJ-m3, T24 and 5673 cell lines

30983072

circ_CEP128

hsa_circ_0102722

miR-145-5p

SOX11

promoted cell proliferation, and decreased cell apoptosis and cell cycle arrest

10 pairs of BCa tissues and adjacent bladder tissues; RT-112, 5637, BIU-87, TCCSUP and HEK293T cell lines

30134837

circ_CEP128

hsa_circ_0102722

miR-145-5p

Myd88

promoted cell proliferation and migration, and decreased cell apoptosis and cell cycle arrest

40 BCa specimens and blood samples; 293T, J82 and T24 cell lines

30939216

circ_0001429

hsa_circ_0001429

miR-205-5p

VEGFA

enhanced cell propagation and metastasis, reduced cell apoptosis, and promoted tumor growth and lung metastasis

20 pairs of BCa tissues and paired adjacent normal bladder tissues; T24 cells and 5637 cells

30909190

circ_TFRC

has_circ_0001445

miR-107

TFRC

promoted the invasion, proliferation and tumor growth, contributed to an EMT phenotype

57 BCa patients tissues compared with adjacent normal patients tissues, EJ, T24, 5637, UMUC3, BIU87, J82, and SW780 cell lines

30782157

circ_ELP3

hsa_circ_0001785

/

/

promoted cell proliferation, and reduced apoptosis and chemosensitivity to cisplatin

18 pairs of tissue samples and 30 bladder cancer samples; T24 and 5647 cells

30745833

circ_PRMT5

hsa_circ_0031250

miR-30c

SNAIL1/E-cadherin

promoted cell EMT

119 UCB tissues with matched adjacent normal bladder tissues; T24, TCC-SUP, 5637, and UM-UC-3 cell lines

30305293

circ_BPTF

hsa_circ_0000799

miR-31-5p

RAB27A

promoted cell migration and invasive, and tumor growth

72 pairs of specimens of BCa tissues and adjacent noncancerous tissues; UM-UC-3 and T24 cell lines

30103209

circ_0000144

hsa_circ_0000144

miR-217

RUNX2

promoted cell proliferation and invasion

21 pairs of BCa tissues and adjacent normal tissues; T24, EJ, UMUC3, RT4 and 253J cell lines

30098434

circ_PTK2

hsa_circ_0003221

/

/

promoted the proliferation and migration

40 pairs of BCa tissue and blood samples. T24 and 5637 cell lines

29125888

circ_MYLK

hsa_circ_0002768

miR-29a

VEGFA/VEGFR2

accelerated cell proliferation, migration, tube formation, and promoted EMT

32 pairs bladder carcinomas and matched para-carcinomas; EJ, T24, 5673 and BIU-87 cell lines

28687357

circ_TCF25

hsa_circ_0041103

miR-103a-3p/miR-107

CDK6

promoted proliferation and migration

40 pairs bladder carcinoma tissue and matched para-carcinoma tissues; T24 and EJ cell lines

27484176

downregulated

circ_FUT8

hsa_circ_0003028

miR-570-3p

KLF10

inhibited migration, invasion, and metastasis

145 BCa tissues and 50 matched adjacent normal bladder tissues; T24, SV-HUC-1, and UM-UC-3 cell lines

32072011

circ_RIP2

hsa_circ_0005777

miR-1305

Tgf-β2/smad3

promoted migration, invasion, clone formation and EMT

45 paired BCa and the adjacent normal tissues, 58 bladder cancer tissues, 5637 and UM-UC-3 cell lines

32019579

circ_FAM114A2

hsa_circ_0001546

miR-762

ΔNP63/TP63

inhibited migration, invasion and proliferation

31 BCa tissues and paired adjacent noncancer tissues; T24, J82, 5637, and 293T cell lines

31969560

circ_0091017

hsa_circ_0091017

miR-589-5p

/

inhibited cell proliferation, migration and invasiveness

40 pairs of BCa tissues and normal adjacent tissues; 5637, EJ, T24, UMUC-3, and RT4 cell lines

31957821

ciRs_6

hsa_circ_0006260

miR-653

March1

suppressed cell growth and increased cell cycle arrest

45 paired bladder cancer and the adjacent normal tissues, 58 bladder cancer tissues; 5637 and UM-UC-3 cell lines

31819015

circ_5912

hsa_circ_0005912

/

TGF-β signaling

suppressesed cell proliferation, invasion and migration

58 BCa tissues and the matched adjacent tissues; T24 and SW780 cell lines

31808751

circ_PTPRA

hsa_circ_0006117

miR-636

KLF9

inhibited cell proliferation and tumor growth

104 BCa specimens, 64 matched BC and adjacent normal specimens; T24 and UM-UC-3 cell lines

31821171

circ_Foxo3

hsa_circ_0006404

miR-191-5p

/

promoted cell apoptosis

30 BCa tissues and adjacent normal bladder tissues; T24, UM-UC-3 and J82 cell lines

31802888

circ_0071662

hsa_circ_0071662

miR-146b-3p

HPGD/NF2

suppressed cell proliferation and invasion

97 BCa tissues and matched adjacent normal tissues; BIU-87, T-24, EJ-28 and J82 cell lines

31757227

circ_PICALM

hsa_circ_0023919

miR-1265

STEAP4

inhibited cell invasion and metastasis

168 BCa samples and 40 corresponding adjacent normal tissue samples; T24, UM-UC-3, J82, RT-4, and HEK-293T cell lines

31648990

circ_0137606

hsa_circ_0137606

miR-1231

PHLPP2

suppressed cell proliferation and metastasis

13 high-grade BCa, low-grade BCa and a normal controlpatients tissues; T24 and SV-HUC-1 cell lines

31545480

circ-ZKSCAN1

hsa_circ_0001727

miR-1178-3p

p21

inhibited cell proliferation, migration, invasion and metastasis

68 BCa tissues and the matched normal tissues; T24, UM-UC-3, 5637, and EJ cell lines

31481066

circ_NR3C1

hsa_circ_0001543

miR-27a-3p

cyclin D1

inhibited cell proliferation, cell cycle progression, and tumor growth

42 pairs of BCa tissues and adjacent normal bladder tissues; T24, EJ, UMUC3, J82, and 5637 cell lines

31255724

circ_SLC8A1

hsa_circ_0000994

miR-130b/miR-494

PTEN

inhibited cell migration, invasion and proliferation

70 pairs of human bladder cancer tissues compared with their adjacent normal tissues; 5637, T24, J82, EJ, UMUC, and RT4 cell lines

31228937

circ_Cdr1as

hsa_circ_0001946

miR-1270

APAF1

induced cell apoptosis and enhanced chemosensitivity to cisplatin

160 BCa tissues; TCCSUP, 5367, T24 and EJ cell lines

31131537

circ_Cdr1as

hsa_circ_0001946

miR-135a

/

inhibited cell proliferation, invasion and migration, and tumour growth

94 pairs of BCa tissues and adjacent normal tissues; EJ and T24 cell lines

29694981

circ_ACVR2A

hsa_circ_0001073

miR-626

EYA4

suppressed cell proliferation and metastasis

50BC tissues and matched adjacent normal epithelial tissues; T24, UM-UC-3, RT4, J82, 5637, HT-1376, and TCCSUP cell lines

31101108

circ_0002024

hsa_circ_0002024

miR-197-3p

/

suppressed cell proliferation, migration, and invasion

20 BCa and normal samples; EJ, 5637, T24, and UMUC-2 cell lines

30972190

circ_CDYL

hsa_circ_0008285

/

C-MYC

inhibited cell growth and migration

30 pairs of BCa tissues and paired surrounding normal bladder tissues; EJ and T24T cells

30968727

circ_LPAR1

hsa_circ_0087960

miR-762

/

inhibited cell invasion and metastasis

125 BCa tissues and 68 paired cancer tissues and adjacent non-tumorous tissues; 5637 and T24 cell lines

30867795

circ_MTO1

hsa_circ_0007874

miR-221

/

inhibited cell EMT and metastasis

117 bladder cancer tissues and the matched adjacent tissues; UMUC3, SVHUC1, T24, J82 and 5637 cell lines

30551873

circ_FNDC3B

hsa_circ_0006156

miR-1178-3p

G3BP2

inhibited cell proliferation, migration, invasion, tumorigenesis and metastasis

82 BCa tissues and 56 pairs of BCa tissues and adjacent noncancerous tissues; T24 and UM-UC-3 cell lines

30458784

circ_UBXN7

hsa_circ_0001380

miR-1247-3p

B4GALT3

inhibited cell proliferation, migration, invasion, and tumor growth

84 cases of BCa tissues including 30 paired BC tissues and adjacent nontumor tissues; SV-HUC-1, T24 and UM-UC-3 cell lines

30312173

circ_HIPK3

hsa_circ_0000284

miR-558

HPSE

inhibited cell migration, invasion, and angiogenesis, tumor growth, and metastasis

44 pairs of bladder cancer tissues and paired adjacent normal bladder tissues; UMUC3, and T24 cell lines

28794202

circ_BCRC3

hsa_circ_0001110

miR-182-5p

p27

inhibited cell proliferation, and impairs tumor growth, and increased cell cycle arrest

47 BCa tissues and their adjacent normal bladder tissues; EJ,T24, and SV-HUC-1 cell lines

30285878

circ_BCRC4

hsa_circ_0001577

miR-101

EZH2

promoted cell apoptosis and inhibited cell viability

24 pairs of fresh bladder cancer tissues and surrounding normal adjacent bladder tissues; UMUC3 and T24 cell lines

29270748

circ_ITCH

hsa_circ_0001141

miR-17, miR-224

p21, PTEN

inhibited cell proliferation, migration, invasion and metastasis, induced cell cycle arrest and cell apoptosis

72 pairs of BCa tumor and normal tissues; UMUC3, T24, J82, 353J, 5637, TCC, EJ and RT4 cell lines

29386015

  1. circRNAs circular RNAs, BCa bladder cancer, EMT epithelial to mesenchymal transition