Table 4 Relationship between circRNAs level and clinicopathologic characteristics in BCa
From: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer
Study | circRNA Name | CircBase ID | Host gene | Position | Cilinical Sample | Detection method | Cut-off value | Reference gene | Dysregulation | Number of patients | Gender | Age | Tumor size | Grade | DF | Stage | LMN | Number of tumors | DM | Invasion | Recurrence | Potential function | AUC | Sensitivity and specifcity | OS | DFS/RFS | PFS | Ref./PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Li et al. | circ_0018069 | hsa circ_0018069 | KIAA1462 | chr10:30315031–30318795 | tissues | qPCR | 0.0007 | β-actin | downregulated | 41 | No | No | No | Yes | – | Yes | No | – | – | Yes | – | Diagnosis | 0.709 | 97.6, 46.3% | – | – | – | 30984788 |
Song et al. | circ_0137439 | hsa_circ_0137439 | MTDH | chr8:98673299–98708521 | urine | qPCR | 1.36 | GAPDH | upregulated | 116 | No | No | – | Yes | – | Yes | Yes | – | – | Yes | – | Diagnosis | 0.89 | 87.93, 80.06% | Yes | Yes | – | 31777254 |
Tang et al. | circ_ASXL1 | hsa_circ_0001136 | ASXL1 | chr20:30954186–30956926 | tissues | qPCR | – | U6 | upregulated | 61 | No | No | No | Yes | – | Yes | Yes | No | Yes | No | – | Diagnosis | 0.77 | 68.6, 76.9% | Yes | – | – | 31966702 |
Zhang et al. | circ_ZFR | hsa_circ_0072088 | ZFR | chr5:32379220–32388780 | tissues | qPCR | MEL | GAPDH | upregulated | 104 | No | No | No | Yes | – | Yes | Yes | – | – | No | Yes | Diagnosis | 0.8216 | – | Yes | – | Yes | 31746333 |
Huang et al. | circ_0000144 | hsa_circ_0000144 | SLAMF6 | chr1:160472466–160472794 | tissues | qPCR | – | U6 | upregulated | 69 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | – | – | 30098434 |
Chi et al. | circ_000285 | hsa_circ_0000285 | HIPK3 | chr11:33362513–33363232 | tissues, serum | qPCR | MV | β-actin | downregulated | 197 | No | No | Yes | – | Yes | Yes | Yes | – | Yes | – | – | – | – | – | Yes | – | – | 30509102 |
Liu et al. | circ_0001361 | hsa_circ_0001361 | FNDC3B | chr3:171830241–171851336 | tissues | qPCR | – | GAPDH | upregulated | 69 | No | No | No | Yes | – | Yes | No | – | – | Yes | – | – | – | – | Yes | – | – | 31705065 |
Mao et al. | circ_0068871 | hsa_circ_0068871 | FGFR3 | chr4:1801473–1804791 | tissues | qPCR | – | GAPDH | upregulated | 32 | No | No | No | – | – | Yes | – | – | No | – | – | – | – | – | – | – | – | 30999937 |
Abulizi et al. | circ_0071662 | hsa_circ_0071662 | TPPP | chr5:659976–693510 | tissues | qPCR | – | – | downregulated | 158 | No | No | Yes | – | – | Yes | – | – | – | – | – | – | – | – | Yes | – | – | 31757227 |
Zhuang et al. | circ_CASC15 | hsa_circ_0075828 | CASC15 | chr6:22020567–22020771 | tissues | qPCR | – | GAPDH | upregulated | 67 | No | No | No | – | – | Yes | No | – | – | – | – | – | – | – | Yes | Yes | – | 31072448 |
Su et al. | circ_5912 | hsa_circ_0005912 | FIP1L1 | chr4:54265896–54294350 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | Yes | No | – | – |  | – | – | – | Yes | – | – | 31808751 |
Bi et al. | circ_BPTF | hsa_circ_0000799 | BPTF | chr17:65941524–65972074 | tissues | qPCR | MEL | – | upregulated | 72 | No | No | No | Yes | – | No | No |  | – | Yes | Yes | – | – | – | Yes | – | – | 30103209 |
Sun et al. | circ_CDYL | hsa_circ_0008285 | CDYL | chr6:4891946–4892613 | tissues | qPCR | – | GAPDH | downregulated | 30 | No | No | – | No | – | Yes | No |  | – | No |  | – | – | – | – | – | – | 30968727 |
Okholm et al. | circ_CDYL | hsa_circ_0008285 | CDYL | chr6:4891946–4892613 | tissues | qPCR | MEL | – | downregulated | 457 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | 29263845 |
Wu et al. | circ_CEP128 | hsa_circ_0102722 | CEP128 | chr14:81209418–81304622 | tissues | qPCR | – | GAPDH | upregulated | 10 | No | No | Yes | – | – | Yes | Yes | – | – | – |  | – | – | – | – | – | – | 30134837 |
Liu et al. | circ_FAM114A2 | hsa_circ_0001546 | FAM114A2 | chr5:153413351–153414527 | tissues | qPCR | NAT | GAPDH | downregulated | 31 | No | No | No | Yes | – | Yes | No | – | – | – |  | – | – | – | – | – | – | 31969560 |
Liu et al. | circ_FNDC3B | hsa_circ_0006156 | FNDC3B | chr3:171965322–171969331 | tissues | qPCR | – | GAPDH | downregulated | 82 | No | No | No | Yes | – | Yes | Yes | – | – | No | No | – | – | – | Yes | – | – | 30458784 |
He et al. | circ_FUT8 | hsa_circ_0003028 | FUT8 | chr14:66028054–66028484 | tissues | qPCR | – | GAPDH | downregulated | 145 | No | No | No | Yes | – | No | Yes | No | – | – | – | – | – | – | Yes | – | – | 32072011 |
Li et al. | circ_HIPK3 | hsa_circ_0000284 | HIPK3 | chr11:33307958–33309057 | tissues | qPCR | – | GAPDH | downregulated | 44 | No | No | – | Yes | – | Yes | Yes | – | – | Yes | – | – | – | – | – | – | – | 28794202 |
Okholm et al. | circ_HIPK3 | hsa_circ_0000284 | HIPK3 | chr11:33307958–33309057 | tissues | qPCR | MEL | – | downregulated | 457 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | 29263845 |
Yang et al. | circ_ITCH | hsa_circ_0001141 | ITCH | chr20:33001547–33037285 | tissues | qPCR | – | β-actin | downregulated | 70 | No | No | No | Yes | – | No | – | – | – | – | – | – | – | – | Yes | – | – | 29386015 |
Lin et al. | circ_LPAR1 | hsa_circ_0087960 | LPAR1 | chr9:113734352–113735838 | tissues | qPCR | – | β-actin | upregulated | 125 | No | No | No | No | – | No | – | No | – | – | No | – | – | – | – | – | – | 30867795 |
Li et al. | circ_MTO1 | hsa_circ_0007874 | MTO1 | chr6:74175931–74176329 | tissues | qPCR | – | β-actin | downregulated | 117 | – | – | – | – | – | – | Yes | – | – | – | – | – | – | – | Yes | Yes | – | 30551873 |
Yan et al. | circ_PICALM | hsa_circ_0023919 | PICALM | chr11:85707868–85714494 | tissues | qPCR | – | GAPDH | downregulated | 168 | No | No | No | Yes | – | Yes | Yes | – | – | – | – | – | – | – | Yes | – | – | 31648990 |
Chen et al. | circ_PRMT5 | hsa_circ_0031250 | PRMT5 | chr14:23395341–23396023 | tissues | qPCR | – | GAPDH | upregulated | 119 | No | No | – | No | – | Yes | – | – | – | – | – | – | – | – | – | Yes | – | 30305293 |
Xu et al. | circ_PTK2 | hsa_circ_0003221 | PTK2 | chr8:141856358–141900868 | tissue, blood | qPCR | – | GAPDH | upregulated | 40 | – | – | – | – | Yes | Yes | Yes | – | – | – | – | – | – | – | – | – | – | 29125888 |
He et al. | circ_PTPRA | hsa_circ_0006117 | PTPRA | chr20:2944917–2945848 | tissues | qPCR | – | GAPDH | downregulated | 104 | No | No | Yes | No | – | Yes | No | No | – | – | – | – | – | – | Yes | – | – | 31821171 |
Su et al. | circ_RIP2 | hsa_circ_0005777 | RGNEF | chr5:73136304–73136585 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | Yes | No | – | – | – | – | – | – | Yes | – | – | 32019579 |
Liang et al. | circ_0058063 | hsa_circ_0058063 | ATIC | chr2:216177220–216213972 | tissues | qPCR | – | GAPDH | upregulated | 94 | No | No | – | Yes | – | Yes | – | No | – | – | – | – | – | – | Yes | – | – | 32181485 |
Wei et al. | circ_403658 | hsa_circ_0004383 | ZNF292 | chr6:87920168–87928449 | tissues | qPCR | – | GAPDH | upregulated | 123 | No | No | Yes | – | – | Yes | No | – | Yes | – | – | – | – | – | Yes | – | – | 31814891 |
Lu et al. | circ_SLC8A1 | hsa_circ_0000994 | SLC8A1 | chr2:40655612–40657444 | tissues | qPCR | – | GAPDH | downregulated | 70 | No | No | – | Yes | – | Yes | No | – | – | – | – | – | – | – | – | – | – | 31228937 |
Su et al. | circ_TFRC | has_circ_0001445 | TFRC | chr3:195785154–195,787,118 | tissues | qPCR | – | GAPDH | upregulated | 220 | No | No | – | Yes | – | Yes | Yes | No | – | – | – | – | – | – | Yes | – | – | 30782157 |
Liu et al. | circ_UBXN7 | hsa_circ_0001380 | UBXN7 | chr3:196118683–196129890 | tissues | qPCR | – | GAPDH | downregulated | 84 | No | No | No | Yes | – | Yes | No | – | – | No | – | – | – | – | Yes | – | – | 30312173 |
Zeng et al. | circ_VANGL1 | hsa_circ_0002623 | VANGL1 | chr1:116202261–116206889 | tissues | qPCR | – | GAPDH | upregulated | 43 | No | No | – | Yes | – | Yes | Yes | – | – | – | – | – | – | – | Yes | – | – | 30146736 |
Bi et al. | circ_ZKSCAN1 | hsa_circ_0001727 | ZKSCAN1 | chr7:99621041–99621930 | tissues | qPCR | – | GAPDH | downregulated | 137 | No | No | No | Yes | – | Yes | Yes | – | – | – | Yes | – | – | – | Yes | Yes | – | 31481066 |
Su et al. | ciRs_6 | hsa_circ_0006260 | SLC41A2 | chr12:105321750–105322472 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | No | No | – | – | – | – | – | – | Yes | – | – | 31819015 |
Liu et al. | circ_0076704 | hsa_circ_0076704 | CD2AP | chr6:47471015–47522502 | tissues | qPCR | – | β-actin | upregulated | 70 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | – | – | 31169020 |
Yang et al. | circ_UVRAG | hsa_circ_0023642 | UVRAG | chr11:75727858–75728024 | tissues | qPCR | – | – | upregulated | 402 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | NO | – | – | 30387298 |
Zhong et al. | circ_MYLK | hsa_circ_0002768 | MYLK | chr3:123471177–123512691 | tissues | qPCR | – | – | upregulated | 32 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes |  | – | 28687357 |