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Table 4 Relationship between circRNAs level and clinicopathologic characteristics in BCa

From: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer

Study circRNA Name CircBase ID Host gene Position Cilinical Sample Detection method Cut-off value Reference gene Dysregulation Number of patients Gender Age Tumor size Grade DF Stage LMN Number of tumors DM Invasion Recurrence Potential function AUC Sensitivity and specifcity OS DFS/RFS PFS Ref./PMID
Li et al. circ_0018069 hsa circ_0018069 KIAA1462 chr10:30315031–30318795 tissues qPCR 0.0007 β-actin downregulated 41 No No No Yes Yes No Yes Diagnosis 0.709 97.6, 46.3% 30984788
Song et al. circ_0137439 hsa_circ_0137439 MTDH chr8:98673299–98708521 urine qPCR 1.36 GAPDH upregulated 116 No No Yes Yes Yes Yes Diagnosis 0.89 87.93, 80.06% Yes Yes 31777254
Tang et al. circ_ASXL1 hsa_circ_0001136 ASXL1 chr20:30954186–30956926 tissues qPCR U6 upregulated 61 No No No Yes Yes Yes No Yes No Diagnosis 0.77 68.6, 76.9% Yes 31966702
Zhang et al. circ_ZFR hsa_circ_0072088 ZFR chr5:32379220–32388780 tissues qPCR MEL GAPDH upregulated 104 No No No Yes Yes Yes No Yes Diagnosis 0.8216 Yes Yes 31746333
Huang et al. circ_0000144 hsa_circ_0000144 SLAMF6 chr1:160472466–160472794 tissues qPCR U6 upregulated 69 Yes 30098434
Chi et al. circ_000285 hsa_circ_0000285 HIPK3 chr11:33362513–33363232 tissues, serum qPCR MV β-actin downregulated 197 No No Yes Yes Yes Yes Yes Yes 30509102
Liu et al. circ_0001361 hsa_circ_0001361 FNDC3B chr3:171830241–171851336 tissues qPCR GAPDH upregulated 69 No No No Yes Yes No Yes Yes 31705065
Mao et al. circ_0068871 hsa_circ_0068871 FGFR3 chr4:1801473–1804791 tissues qPCR GAPDH upregulated 32 No No No Yes No 30999937
Abulizi et al. circ_0071662 hsa_circ_0071662 TPPP chr5:659976–693510 tissues qPCR downregulated 158 No No Yes Yes Yes 31757227
Zhuang et al. circ_CASC15 hsa_circ_0075828 CASC15 chr6:22020567–22020771 tissues qPCR GAPDH upregulated 67 No No No Yes No Yes Yes 31072448
Su et al. circ_5912 hsa_circ_0005912 FIP1L1 chr4:54265896–54294350 tissues qPCR GAPDH downregulated 58 No No Yes Yes Yes No   Yes 31808751
Bi et al. circ_BPTF hsa_circ_0000799 BPTF chr17:65941524–65972074 tissues qPCR MEL upregulated 72 No No No Yes No No   Yes Yes Yes 30103209
Sun et al. circ_CDYL hsa_circ_0008285 CDYL chr6:4891946–4892613 tissues qPCR GAPDH downregulated 30 No No No Yes No   No   30968727
Okholm et al. circ_CDYL hsa_circ_0008285 CDYL chr6:4891946–4892613 tissues qPCR MEL downregulated 457 Yes 29263845
Wu et al. circ_CEP128 hsa_circ_0102722 CEP128 chr14:81209418–81304622 tissues qPCR GAPDH upregulated 10 No No Yes Yes Yes   30134837
Liu et al. circ_FAM114A2 hsa_circ_0001546 FAM114A2 chr5:153413351–153414527 tissues qPCR NAT GAPDH downregulated 31 No No No Yes Yes No   31969560
Liu et al. circ_FNDC3B hsa_circ_0006156 FNDC3B chr3:171965322–171969331 tissues qPCR GAPDH downregulated 82 No No No Yes Yes Yes No No Yes 30458784
He et al. circ_FUT8 hsa_circ_0003028 FUT8 chr14:66028054–66028484 tissues qPCR GAPDH downregulated 145 No No No Yes No Yes No Yes 32072011
Li et al. circ_HIPK3 hsa_circ_0000284 HIPK3 chr11:33307958–33309057 tissues qPCR GAPDH downregulated 44 No No Yes Yes Yes Yes 28794202
Okholm et al. circ_HIPK3 hsa_circ_0000284 HIPK3 chr11:33307958–33309057 tissues qPCR MEL downregulated 457 Yes 29263845
Yang et al. circ_ITCH hsa_circ_0001141 ITCH chr20:33001547–33037285 tissues qPCR β-actin downregulated 70 No No No Yes No Yes 29386015
Lin et al. circ_LPAR1 hsa_circ_0087960 LPAR1 chr9:113734352–113735838 tissues qPCR β-actin upregulated 125 No No No No No No No 30867795
Li et al. circ_MTO1 hsa_circ_0007874 MTO1 chr6:74175931–74176329 tissues qPCR β-actin downregulated 117 Yes Yes Yes 30551873
Yan et al. circ_PICALM hsa_circ_0023919 PICALM chr11:85707868–85714494 tissues qPCR GAPDH downregulated 168 No No No Yes Yes Yes Yes 31648990
Chen et al. circ_PRMT5 hsa_circ_0031250 PRMT5 chr14:23395341–23396023 tissues qPCR GAPDH upregulated 119 No No No Yes Yes 30305293
Xu et al. circ_PTK2 hsa_circ_0003221 PTK2 chr8:141856358–141900868 tissue, blood qPCR GAPDH upregulated 40 Yes Yes Yes 29125888
He et al. circ_PTPRA hsa_circ_0006117 PTPRA chr20:2944917–2945848 tissues qPCR GAPDH downregulated 104 No No Yes No Yes No No Yes 31821171
Su et al. circ_RIP2 hsa_circ_0005777 RGNEF chr5:73136304–73136585 tissues qPCR GAPDH downregulated 58 No No Yes Yes Yes No Yes 32019579
Liang et al. circ_0058063 hsa_circ_0058063 ATIC chr2:216177220–216213972 tissues qPCR GAPDH upregulated 94 No No Yes Yes No Yes 32181485
Wei et al. circ_403658 hsa_circ_0004383 ZNF292 chr6:87920168–87928449 tissues qPCR GAPDH upregulated 123 No No Yes Yes No Yes Yes 31814891
Lu et al. circ_SLC8A1 hsa_circ_0000994 SLC8A1 chr2:40655612–40657444 tissues qPCR GAPDH downregulated 70 No No Yes Yes No 31228937
Su et al. circ_TFRC has_circ_0001445 TFRC chr3:195785154–195,787,118 tissues qPCR GAPDH upregulated 220 No No Yes Yes Yes No Yes 30782157
Liu et al. circ_UBXN7 hsa_circ_0001380 UBXN7 chr3:196118683–196129890 tissues qPCR GAPDH downregulated 84 No No No Yes Yes No No Yes 30312173
Zeng et al. circ_VANGL1 hsa_circ_0002623 VANGL1 chr1:116202261–116206889 tissues qPCR GAPDH upregulated 43 No No Yes Yes Yes Yes 30146736
Bi et al. circ_ZKSCAN1 hsa_circ_0001727 ZKSCAN1 chr7:99621041–99621930 tissues qPCR GAPDH downregulated 137 No No No Yes Yes Yes Yes Yes Yes 31481066
Su et al. ciRs_6 hsa_circ_0006260 SLC41A2 chr12:105321750–105322472 tissues qPCR GAPDH downregulated 58 No No Yes Yes No No Yes 31819015
Liu et al. circ_0076704 hsa_circ_0076704 CD2AP chr6:47471015–47522502 tissues qPCR β-actin upregulated 70 Yes 31169020
Yang et al. circ_UVRAG hsa_circ_0023642 UVRAG chr11:75727858–75728024 tissues qPCR upregulated 402 NO 30387298
Zhong et al. circ_MYLK hsa_circ_0002768 MYLK chr3:123471177–123512691 tissues qPCR upregulated 32 Yes   28687357
  1. circRNAs circular RNAs, BCa bladder cancer, MV mean value, MEL median expression level, LNM lymph nodes metastasis, NAT adjacent noncancerous tissues, DF differentiation, LNM lymph node metastasis, DM distant metastasis, AUC area under the curve, OS over survival, DFS disease-free survival, RFS recurrence-free survival, PFS progression-free survival