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Fig. 10 | Molecular Cancer

Fig. 10

From: Long non-coding RNA UCA1 promotes malignant phenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as a ceRNA

Fig. 10

The effect of UCA1 on tumorigenicity of renal cancer cells. Tumors collected from mice were exhibited (a). The relative expression level of UCA1 was significantly down-regulated by LV-UCA1 (b). Tumor weight of LV-UCA1 or LV-NC treatment groups were measured and analyzed (c). Tumor volume curve of LV-UCA1 or LV-NC treatment groups were measured and analyzed (d). Knockdown of UCA1 decreased DLL4, NICD and Hes1 expression, and increased DLL1, Jag1, Jag2 and Notch1 expression in renal cancer cells (e and f). Knockdown of UCA1 decreased DLL4 expression of renal cancer cells in vivo (g). Data were shown as mean ± standard deviation (SD) of those biological replicates or samples (*P < 0.05, **P < 0.01)

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