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Fig. 1 | Molecular Cancer

Fig. 1

From: lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Fig. 1

JPX was ectopically overexpressed in lung cancer tissues and cells. (a) The heatmap of differentially expressed lncRNAs from four pairs of lung cancer tissues and matched adjacent normal tissues. The red color on the side of the row represents the upregulated lncRNAs in lung cancer, while the green color represents downregulated lncRNAs. (b) Venn diagram showing overlapping lncRNAs from the results of lncRNA microarray analysis and starBase database prediction. (c)Targeted sites between miR-33a-5p and JPX in starBase database. (d)Relative JPX expression detected by RT-qPCR in 116 paired lung cancer and noncancerous tissues. Results are presented as 2-ΔΔCt in tumor tissues relative to normal tissues. (e)Relative JPX expression of in lung cancer tissues was divided into 58 high-expression groups and 58 low-expression groups according to the median. (f, g)Relative JPX expression in lung cancer tissues with different TNM stages and with or without metastasis. (h)RT-qPCR analysis of the relative JPX expression in four lung cancer cell lines (SPC-A-1, LTEP-a-2, A549, NCI-H1299) and a normal lung epithelial cell line (BEAS-2B). Data are presented as the mean ± SD from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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