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Fig. 7 | Molecular Cancer

Fig. 7

From: lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Fig. 7

JPX promoted Twist1 expression in lung cancer cells. (a) Relative Twist1 expression in 95 lung cancer tissues and matched noncancerous tissues. (b) The relationship between Twist1 and JPX expression in 20 lung cancer tissues using Pearson’s correlation analysis. (c) Correlation analysis between JPX and miR-33a-5p expression in 20 lung cancer tissues. (d) Relative Twist1 expression in lung cancer cell lines compared with that in the normal epithelial cell line. The relative expression levels of JPX (e) and Twist1 (f) in tumor tissues from the xenograft models. (g) Twist1 protein expression when transfected with enhanced JPX. (h, i) Based on JPX expression, the qRT-PCR data from clinical samples was classified as JPX high and JPX low. Relative Twist1 mRNA expression was compared with JPX and using box plots. (j, k) Based on Twist1 mRNA expression, the qRT-PCR data from clinical samples were classified as the “Twist1 high” and the “Twist1 low”. Relative JPX expression was compared with Twist1 mRNA using box plots. Data are shown as the mean ± SD, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001

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