lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Table 1 Correlations between JPX and clinical characteristics of 116 lung cancer patients

	n	lncRNA JPX level^†		χ² test	P value
Characteristics		High	Low
Total cases	116	58	58
Gender
Male	66	34	32	0.1406	0.7077
Female	50	24	26
Age (years)
≤ 60	40	18	22	0.6105	0.4346
>60	76	40	36
Smoking history
Yes	47	26	21	0.8942	0.3443
No	69	32	37
Histology
Adenocarcinoma	84	41	43	0.2015	0.9042
Squamous carcinoma	26	14	12
Other type	6	3	3
Tumor location
Left	55	24	31	1.694	0.193
Right	61	34	27
Differentiation
High and moderate	21	11	10	0.05815	0.8095
Poor	95	47	48
Tumor size(cm)
≤ 3	84	34	50	11.05	0.0009^**
>3	32	24	8
TNM stage
I + II	87	35	52	13.29	0.0003^***
III + IV	29	23	6

†Median expression level was used as cutoff. Low expression of JPX in 116 patients was defined as a value below the 50th percentile, and high above the 50th percentile. P values were acquired by Pearson’s chi-square test. **P < 0.01, ***P < 0.001

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