Fig. 1

SNHG12 is up-regulated in TMZ-resistant GBM tissues and cell lines. a Hierarchical clustering analysis of lncRNAs that were differentially expressed in glioma samples. b Overlap of lncRNAs in the CGGA, Rembrandt, and GEO data sets c The expression level of SNHG12 in TMZ-resistant and TMZ-sensitive cells. d Relative expression of SNHG12 in primary and recurrent GBM tissues. The SNHG12 expression was normalized to β-actin. e FISH analysis of SNHG12 expression in normal brain tissues, primary GBM tissues and recurrent tissues. Scale bar = 50 μm. f Kaplan-Meier survival analysis of OS in GBM patients with TMZ chemotherapy (n = 40, P = 0.0085). Data are presented as the mean ± SEM from three independent experiments. Significant results were presented as NS non-significant, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001