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Fig. 8 | Molecular Cancer

Fig. 8

From: DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma

Fig. 8

Knockdown of SNHG12 restores TMZ sensitivity in TMZ-resistant GBM xenografts. a Representative bioluminescence images of intracranial xenografts bearing SNHG12-depleted or control Rec GBM cells in the absence or presence of TMZ treatment on the days as indicated. b Immunohistochemistry staining of Ki67, Cleaved caspase-3, MAPK1 and E2F7. Scale bar = 50 μm (c) Kaplan-Meier survival curve of nude mice is shown. d The mechanistic scheme of DNA-methylation-mediated activating of lncRNA SNHG12 in regulating GBM cell proliferation and temozolomide resistance

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Molecular Cancer

ISSN: 1476-4598