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Table 2 ATG proteins of mammals in the core machinery of autophagosome formation

From: Autophagy and autophagy-related proteins in cancer

Complex Components Roles of the proteins in the core machinery
The ULK kinase core complex ULK1/2 Protein kinase and recruitment of ATG proteins to the PAS
ATG13 ULK-binding protein and linker between ULK1/2 and FIP200
RB1CC1/FIP200 Scaffold protein for ULK1/2 and ATG13
ATG101 ATG13-binding protein
The class III PI3K complex I VPS34 PtdIns 3-kinase catalytic subunit
VPS15 Serine/Threonine protein kinase
Beclin1 Component of PtdIns3K complex I and II
ATG14L Component of PtdIns3K complex I
The ATG9A/ATG2-WIPI1/2 trafficking system ATG9A Transmembrane protein required for autophagosome formation
WIPI1/2 PtdIns3P-binding protein
ATG2A Interacts with WIPI1/2
The ATG12-conjugation system ATG12 Ubiquitin-like protein conjugated to ATG5
ATG7 E1-like enzyme
ATG10 E2-like enzyme
ATG5 Conjugated by ATG12
ATG16L1 Interacts with ATG12 and ATG5
The LC3-conjugation system LC3A-C, GABARAPs, GATE-16 Ubiquitin-like protein conjugated to PE
ATG7 E1-like enzyme
ATG3 E2-like enzyme
ATG4A-D LC3 carboxy-terminal protease, and deconjugating