Fig. 1
From: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer
Expression profiles of circRNAs in CRC and characterization of circPTK2. a Heatmap of the differentially expressed circRNAs in six pairs of human CRC tissues and adjacent non-tumor tissues. Red: upregulated circRNAs in CRC; green: downregulated circRNAs in CRC. b circPTK2 is back-spliced by exons 27, 28, and 29 of PTK2. c, d Cells were treated with hypoxia. circPTK2 was detected by RNAscope. Location and expression of circPTK2 in SW620 and LOVO cells. e, f Location and expression of circPTK2 in SW480 and HCT15 cells. g Location and expression of circPTK2 in adjacent and tumor of patient tissue. P values were calculated by one-way ANOVA