microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

Kanchan, Ranjana K.; Siddiqui, Jawed A.; Mahapatra, Sidharth; Batra, Surinder K.; Nasser, Mohd W.

doi:10.1186/s12943-020-1140-x

Molecular Cancer

Table 1 miRNAs mediated regulation of BCBM

From: microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

miRNA	Targets	Regulation	References
EMT
miR-8084	ING2, p53-BAX	upregulated	[16]
miR-484	PAX-5	upregulated	[19]
miR-708-3p	ZEB1, CDH2 and vimentin	downregulated	[17]
miR-210	E-cadherin (ORF), PAX-5	upregulated	[19]
miR-142-3p	Bach-1, CXCR4, MMP9, and VEGFR	downregulated	[18]
miR-199a/214	Slug	downregulated	[51]
miR-3178	Notch1	downregulated	[52]
miR-212-5p	Prrx2	downregulated	[53]
miR-29,miR-30 miR-200 family	ADAM12-L	downregulated	[54]
Intravasation
miR-126	VEGF/PI3K/AKT axis, MAPK	downregulated	[30]
miR-520/373	ANGPTL4, PTHrP, PAI-1	downregulated	[25]
miR-204	ANGPT1 and TGFβR2	downregulated	[24]
miR-200 family	IL-8 and CXCL1	downregulated	[27]
miR-105	ZO-1	downregulated	[29]
Intravascular Microenvironment
miR-141	Protection in circulation	upregulated	[31]
miR-183	DAP12/NK cells	downregulated	[32]
Extravasation in Brain Microenvironment
miR-7, let-7c, miR-21	FasL, SERPIN1	upregulated	[55]
miR-200c	FAP-1	downregulated	[56]
miR-206	Cx43	downregulated	[57]
miR-19a, miR-32,miR-124a, miR-130b, miR-148a, and miR-583	PCTH7	downregulated	[58]
miR-125a/b-5p	ET-1	downregulated	[59]
miR-1266, miR-185 and miR-30c	BCL2L1	downregulated	[60]
miR-151-3p	TWIST1	downregulated	[61]
miR-17	ICAM-1and E-Selectin	downregulated	[62]
miR-126 and miR-1185	VCAM1	downregulated	[63]
miR-483-5p	ALCAM	downregulated	[64]
miR-21-3p	L1CAM	upregulated	[34]
miR-212	HBEGF	downregulated	[65]
miR-655	COX2	downregulated	[66]
miR-200b, 200c	ST6GALNAC5	downregulated	[67, 68]
BBB Regulation
miR-181c	PDPK1	upregulated	[69]
miR-143	PUMA	upregulated	[35]
miR-125a-5p	ICAM-1	downregulated	[38]
miR-1258	HPSE	downregulated	[40]
miR-210	Occludin, β-catenin	upregulated	[37]
Cross Talk and Niche Formation
miR-26a	PTEN ATM	upregulated	[70, 71]
miR-19a	PTEN	upregulated	[42]
miR-345	KISS1	upregulated	[72]
miR-124, miR-155, miR-689	Associated with M1 phenotype of microglia	upregulated	[73]
miR-711 and miR-145	Associated with M2 phenotype of microglia	upregulated	[73]
miR-503	L1CAM trigger M1–M2 polarization of microglia	upregulated	[41]
Metabolic Reprogramming
miR-122	PKM2 , GLUT-1	upregulated	[74]
miR-155	PIK3R1-PDK/AKT-FOXO3a-cMYC axis	downregulated	[75]
miR-7	RelA	upregulated	[76]
Colonization
miR-200 family (miR-200a,200b, 200c, miR-141, and miR-429)	ZEB1 and ZEB2	upregulated	[43, 44]
miR-147	ZEB1	upregulated
miR-126	IGFBP2, PITPNC1 and MERTK	downregulated	[77]

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ISSN: 1476-4598

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