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Fig. 2 | Molecular Cancer

Fig. 2

From: Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

Fig. 2

The effect of SOX2OT on the BCSC self-renewal ability and apoptosis. a: SOX2OT-specific shRNAs significantly decreased SOX2OT expression in BCSCs. b and c: Changes in BCSC proliferation were determined using the EdU assay. d and e: Changes in the colony forming ability of BCSCs were determined using a colony-formation assay. f and g: Changes in the spheroid-formation ability of BCSCs were determined using tumour sphere formation. h and i: Changes in the spheroid-formation ability of BCSCs were also determined using single-cell tumour sphere formation. j and k: There was no difference in apoptosis of BCSCs transfected with the corresponding specific shRNA. The data are shown as the mean ± SD. *p < 0.05; **p < 0.01

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