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Fig. 4 | Molecular Cancer

Fig. 4

From: Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2

Fig. 4

SOX2OT promotes the stemness phenotype of BCSC by modulating SOX2. a SOX2OT expression level was positively correlated with SOX2 expression level in BC. b Knockdown of SOX2OT decreased SOX2 expression in BCSCs. c The expression of SOX2 and SOX2 target genes were determined using RT-qPCR. d The SOX2 vector significantly reversed the expression level of SOX2 in BCSCs. e and f Overexpressing SOX2 significantly reversed the spheroid-formation ability inhibition induced by silencing SOX2OT. g and h Overexpressing SOX2 significantly reversed the colony forming ability inhibition induced by silencing SOX2OT. i and j Overexpressing SOX2 significantly reversed the cell migration inhibition induced by silencing SOX2OT. k and l Overexpressing SOX2 significantly reversed the cell invasion inhibition induced by silencing SOX2OT

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Molecular Cancer

ISSN: 1476-4598