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Fig. 7 | Molecular Cancer

Fig. 7

From: Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

Fig. 7

Combination therapeutic strategy to enhance T cell activation and T immune cell function and infiltration. There are approximately five types of combined treatment strategies. Combinations with anti-PD-1/PD-L1 agents can induce better therapeutic effects by inducing immunogenic cell death and restoring the function of the tumor suppressor p53. We summarize the combinations with B2M, HSCs (CCR2+), HDAC, and other cells and molecules. We describe a number of ways to inhibit MDSCs and thereby enhance therapeutic efficacy. Various molecules, including IL-15, CD96, CD47, and CD137 have potential inhibitory effects. We also summarize receptor-mediated and combination therapeutic strategies for the activation of inflammatory pathways and immune cells

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