TY - JOUR AU - Han, Mingli AU - Gu, Yuanting AU - Lu, Pengwei AU - Li, Jingyi AU - Cao, Hui AU - Li, Xiangke AU - Qian, Xueke AU - Yu, Chao AU - Yang, Yunqing AU - Yang, Xue AU - Han, Na AU - Dou, Dongwei AU - Hu, Jianguo AU - Dong, Huaying PY - 2020 DA - 2020/02/05 TI - RETRACTED ARTICLE: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation JO - Molecular Cancer SP - 26 VL - 19 IS - 1 AB - Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and chemoresistance. However, the regulatory mechanism of lncRNAs in trastuzumab resistance is not well established to date. In this research, we identified the differentially expressed lncRNA and investigated its regulatory role in trastuzumab resistance of breast cancer. SN - 1476-4598 UR - https://doi.org/10.1186/s12943-020-1145-5 DO - 10.1186/s12943-020-1145-5 ID - Han2020 ER -