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Fig. 9 | Molecular Cancer

Fig. 9

From: RETRACTED ARTICLE: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation

Fig. 9

A scheme of the proposed mechanisms. Trastuzumab treatment increases AFAP1-AS1 expression; which upregulates HER-2 expression by guiding AUF1 to activate the translation of ERBB2 mRNA, inducing trastuzumab resistance. In addition, extracellular AFAP1-AS1 from trastuzumab-resistant cells was packaged into exosomes and disseminates trastuzumab resistance in trastuzumab sensitive cells

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Molecular Cancer

ISSN: 1476-4598