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Fig. 3 | Molecular Cancer

Fig. 3

From: METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

Fig. 3

Knockdown of METTL14 promoted proliferation and invasion of CRC in vivo. a Xenograft tumors formed by HCT116-shMETTL14 or -shNC cells in nude mice. b-c Quantitative analysis of tumor volume (b) and tumor weight (c) of xenografts. Tumor volume was compared at indicated time points and tumor weight was measured at the end point. *, p < 0.05, **, p < 0.01. d Xenograft tumor sections stained with hematoxylin and eosin (HE), METTL14 and Ki-67 were examined by immunohistochemistry. Magnification, 200×. e Analysis of METTL14 IHC score and Ki-67 positive rate in xenograft tumor tissue from different groups. **, p < 0.01. f Analysis of metastatic liver nodules in different group of mice. Liver tissue of mice were counterstained with HE and typical metastatic lesions were indicated with black arrow. **, p < 0.01. P values were determined by Student’s t-test

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Molecular Cancer

ISSN: 1476-4598