Fig. 1
From: Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Small peptides encoded by circRNAs and lncRNAs regulate tumor proliferation. aCircSHPRH encodes SHPRH-146aa, which protects full-length SHPRH from ubiquitin protease degradation. SHPRH ubiquitinates PCNA as an E3 ligase. bCirc-AKT3 encodes AKT3-174aa, which competitively interacts with PDK1 to negatively regulate the PI3K/Akt signaling pathway. cCircPINT encodes PINT87aa, which interacts with PAF1 and inhibits transcriptional elongation of oncogenes. dCirc-FBXW7 encodes Fbxw7-185aa, which prevents interaction between USP28 and FBXW7a by competitively binding USP28 and destabilizing c-Myc. eCircE7 encodes the E7 oncoprotein, which promotes tumor proliferation. f The lncRNA UBAP1-AST6 encodes UBAP1-AST6, which is a cancer-promoting factor