Fig. 2
From: Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Small peptides encoded by circRNAs and lncRNAs regulate tumor invasion, metastasis, and proliferation. aCircPPP1R12A encodes circPPP1R12A-73aa, which activates the Hippo-YAP signaling pathway. b The lncRNA HOXB-AS3 encodes the HOXB-AS3 peptide, which competitively binds hnRNP A1 and antagonizes hnRNP A1-mediated PKM splicing regulation. cCircLgr4 encodes circLgr4-peptide, which interacts with LGR4 and activates the LGR4-Wnt signaling pathway. dCircβ-catenin encodes β-catenin-370aa, which antagonizes GSK3β-induced β-catenin phosphorylation and ubiquitination/degradation, stabilizes full-length β-catenin, and activates the Wnt pathway. eLINC01420 encodes nobody, which binds EDC4 to regulate mRNA degradation. LINC01420 may promote nasopharyngeal carcinoma invasion and metastasis via this pathway