Fig. 7
From: The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
IKKα – c-Myc activation model. c-Myc is phosphorylated by ERK, GSK3β or other kinases on serine-62. GSK3β further phosphorylates c-Myc on threonine-58 leading to dephosphorylation of serine-62 and subsequent ubiquitination and proteasomal degradation. IKKα interacts with c-Myc and phosphorylates it at serine-67 and serine-71 presumably in the nucleus, leading to a subsequent inhibition of GSK3β-mediated phosphorylation of threonine-58 followed by stabilization and increased transcriptional activity of c-Myc leading to an increase in proliferation and a decrease in apoptosis